Vibrational spectroscopy: Disease diagnostics and beyond

Hugh J. Byrne, Kamila M. Ostrowska, Haq Nawaz, Jennifer Dorney, Aidan D. Meade, Franck Bonnier, Fiona M. Lyng

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

This chapter outlines some developments in the applications of vibrational spectroscopy for disease diagnostics and demonstrates how the applications of the spectroscopic techniques can be extended to the analysis and evaluation of disease aetiology and the mechanisms of interaction with and the cellular and subcellular responses to, for example, chemotherapeutic agents and nanoparticles. The primary emphasis is on Raman spectroscopy, although some examples are based on infrared absorption spectroscopy. The studies presented are chosen to illustrate how a range of multivariate analytical techniques can be employed to maximize the potential benefits of the complex spectral information obtained from tissue or cells.

Original languageEnglish
Title of host publicationOptical Spectroscopy and Computational Methods in Biology and Medicine
PublisherSpringer Netherlands
Pages355-399
Number of pages45
DOIs
Publication statusPublished - 1 Jan 2014

Publication series

NameChallenges and Advances in Computational Chemistry and Physics
Volume14
ISSN (Print)2542-4491
ISSN (Electronic)2542-4483

Keywords

  • Cervical Cancer
  • Cervical Intraepithelial Neoplasia
  • Human Papilloma Virus
  • Partial Little Square Regression
  • Vibrational Spectroscopy

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