TY - JOUR
T1 - Transmission protocols for calcium-signaling-based molecular communications in deformable cellular tissue
AU - Barros, Michael Taynnan
AU - Balasubramaniam, Sasitharan
AU - Jennings, Brendan
AU - Koucheryavy, Yevgeni
PY - 2014/7
Y1 - 2014/7
N2 - Molecular communications is a new paradigm that enables nanomachines to communicate within a biological environment. One form of molecular communications is calcium (Ca2+) signaling, which occurs naturally in living biological cells. Ca2+ signaling enables cells in a tightly packed tissue structure to communicate at short ranges with neighboring cells. The achievable mutual information of Ca2+ signaling between tissue embedded nanomachines is investigated in this paper, focusing in particular on the impact that the deformation of the tissue structure has on the communication channel. Based on this analysis, a number of transmission protocols are proposed; nanomachines can utilize these to communicate using Ca2+ signaling. These protocols are static time-slot configuration, dynamic time-slot configuration, dynamic time-slot configuration with silent communication, and improved dynamic time-slot configuration with silent communication (IDTC-SC). The results of a simulation study show that IDTC-SC provides the maximum data rate when tissues experience frequent deformation.
AB - Molecular communications is a new paradigm that enables nanomachines to communicate within a biological environment. One form of molecular communications is calcium (Ca2+) signaling, which occurs naturally in living biological cells. Ca2+ signaling enables cells in a tightly packed tissue structure to communicate at short ranges with neighboring cells. The achievable mutual information of Ca2+ signaling between tissue embedded nanomachines is investigated in this paper, focusing in particular on the impact that the deformation of the tissue structure has on the communication channel. Based on this analysis, a number of transmission protocols are proposed; nanomachines can utilize these to communicate using Ca2+ signaling. These protocols are static time-slot configuration, dynamic time-slot configuration, dynamic time-slot configuration with silent communication, and improved dynamic time-slot configuration with silent communication (IDTC-SC). The results of a simulation study show that IDTC-SC provides the maximum data rate when tissues experience frequent deformation.
KW - Calcium signaling
KW - deformable tissue
KW - molecular communications
KW - transmission protocols
UR - http://www.scopus.com/inward/record.url?scp=84904293270&partnerID=8YFLogxK
U2 - 10.1109/TNANO.2014.2321492
DO - 10.1109/TNANO.2014.2321492
M3 - Article
AN - SCOPUS:84904293270
SN - 1536-125X
VL - 13
SP - 779
EP - 788
JO - IEEE Transactions on Nanotechnology
JF - IEEE Transactions on Nanotechnology
IS - 4
M1 - 6809215
ER -