TY - JOUR
T1 - Towards 3D in vitro models for the study of cardiovascular tissues and disease
AU - Ryan, Alan J.
AU - Brougham, Claire M.
AU - Garciarena, Carolina D.
AU - Kerrigan, Steven W.
AU - O'Brien, Fergal J.
N1 - Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/9/1
Y1 - 2016/9/1
N2 - The field of tissue engineering is developing biomimetic biomaterial scaffolds that are showing increasing therapeutic potential for the repair of cardiovascular tissues. However, a major opportunity exists to use them as 3D in vitro models for the study of cardiovascular tissues and disease in addition to drug development and testing. These in vitro models can span the gap between 2D culture and in vivo testing, thus reducing the cost, time, and ethical burden of current approaches. Here, we outline the progress to date and the requirements for the development of ideal in vitro 3D models for blood vessels, heart valves, and myocardial tissue.
AB - The field of tissue engineering is developing biomimetic biomaterial scaffolds that are showing increasing therapeutic potential for the repair of cardiovascular tissues. However, a major opportunity exists to use them as 3D in vitro models for the study of cardiovascular tissues and disease in addition to drug development and testing. These in vitro models can span the gap between 2D culture and in vivo testing, thus reducing the cost, time, and ethical burden of current approaches. Here, we outline the progress to date and the requirements for the development of ideal in vitro 3D models for blood vessels, heart valves, and myocardial tissue.
UR - http://www.scopus.com/inward/record.url?scp=84966709816&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2016.04.014
DO - 10.1016/j.drudis.2016.04.014
M3 - Review article
C2 - 27117348
AN - SCOPUS:84966709816
SN - 1359-6446
VL - 21
SP - 1437
EP - 1445
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 9
ER -