The role of obesity in gastrointestinal cancer: Evidence and opinion

Claire L. Donohoe; Naoimh J. Ofarrell; Suzanne L. Doyle; John V. Reynolds

doi:10.1177/1756283X13501786

The role of obesity in gastrointestinal cancer: Evidence and opinion

Claire L. Donohoe, Naoimh J. Ofarrell, Suzanne L. Doyle, John V. Reynolds

School of Biological, Health and Sports Sciences

Research output: Contribution to journal › Review article › peer-review

36 Citations (Scopus)

Abstract

There is increasing recognition of the impact of being overweight and obese on the development of cancers at diverse sites including the gastrointestinal tract. Large epidemiological studies indicate that up to 14% of tumours may be related to obesity. Pathophysiological mechanisms underpinning this association are not well understood and so are discussed in this review.

Original language	English
Pages (from-to)	38-50
Number of pages	13
Journal	Therapeutic Advances in Gastroenterology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1177/1756283X13501786
Publication status	Published - Jan 2014

Keywords

adipose tissue, carcinogenesis
inflammation
signalling pathways
visceral adiposity

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title = "The role of obesity in gastrointestinal cancer: Evidence and opinion",

abstract = "There is increasing recognition of the impact of being overweight and obese on the development of cancers at diverse sites including the gastrointestinal tract. Large epidemiological studies indicate that up to 14% of tumours may be related to obesity. Pathophysiological mechanisms underpinning this association are not well understood and so are discussed in this review.",

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author = "Donohoe, {Claire L.} and Ofarrell, {Naoimh J.} and Doyle, {Suzanne L.} and Reynolds, {John V.}",

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AU - Reynolds, John V.

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AB - There is increasing recognition of the impact of being overweight and obese on the development of cancers at diverse sites including the gastrointestinal tract. Large epidemiological studies indicate that up to 14% of tumours may be related to obesity. Pathophysiological mechanisms underpinning this association are not well understood and so are discussed in this review.

KW - adipose tissue, carcinogenesis

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KW - signalling pathways

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The role of obesity in gastrointestinal cancer: Evidence and opinion

Abstract

Keywords

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