Targeting Lipoprotein Biogenesis: Considerations towards Antimicrobials

Toufic El Arnaout, Tewfik Soulimane

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    Decades have passed without approval of a new antibiotic class. Several companies have recently halted related discovery efforts because of multiple obstacles. One promising route under research is to target the lipoprotein maturation pathway in light of major recent findings and the virulence roles of lipoproteins. To support the future design of selective drugs, considerations and priority-setting are established for the main lipoprotein processing enzymes (Lgt, LspA, and Lnt) based on microbiology, biochemistry, structural biology, chemical design, and pharmacology. Although not all bacterial species will be similarly impacted by drug candidates, several advantages make LspA a top target to pursue in the development of novel antibiotics effective against bacteria that are resistant to existing drugs.

    Original languageEnglish
    Pages (from-to)701-715
    Number of pages15
    JournalTrends in Biochemical Sciences
    Volume44
    Issue number8
    DOIs
    Publication statusPublished - Aug 2019

    Keywords

    • antibiotic resistance
    • drug design
    • lipid transferase
    • lipoproteins
    • signal peptidase

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