Synthesis of peptidomimetics based on iminosugar and β-D- glucopyranoside scaffolds and inhibiton of HIV-protease

Florence Chery; Linda Cronin; Julie L. O'Brien; Paul V. Murphy

doi:10.1016/j.tet.2004.05.080

Synthesis of peptidomimetics based on iminosugar and β-D- glucopyranoside scaffolds and inhibiton of HIV-protease

Florence Chery
, Linda Cronin
, Julie L. O'Brien
, Paul V. Murphy

Research output: Contribution to journal › Article › peer-review

Abstract

Synthetic routes to peptidomimetic compounds derived from saccharide scaffolds are described. The regioselective introduction of pivaloyl groups was achieved from N-benzyloxycarbonyl protected 1-deoxymannojirimycin or via D-fructopyranosides. The results from biological evaluation of the saccharide derivatives as HIV-protease inhibitors are included.

Original language	English
Pages (from-to)	6597-6608
Number of pages	12
Journal	Tetrahedron
Volume	60
Issue number	31
DOIs	https://doi.org/10.1016/j.tet.2004.05.080
Publication status	Published - 26 Jul 2004
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Azasugar
Glucopyranoside
HIV-protease
Iminosugar
Peptidomimetic

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10.1016/j.tet.2004.05.080

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title = "Synthesis of peptidomimetics based on iminosugar and β-D- glucopyranoside scaffolds and inhibiton of HIV-protease",

abstract = "Synthetic routes to peptidomimetic compounds derived from saccharide scaffolds are described. The regioselective introduction of pivaloyl groups was achieved from N-benzyloxycarbonyl protected 1-deoxymannojirimycin or via D-fructopyranosides. The results from biological evaluation of the saccharide derivatives as HIV-protease inhibitors are included.",

keywords = "Azasugar, Glucopyranoside, HIV-protease, Iminosugar, Peptidomimetic",

author = "Florence Chery and Linda Cronin and O'Brien, \{Julie L.\} and Murphy, \{Paul V.\}",

year = "2004",

month = jul,

day = "26",

doi = "10.1016/j.tet.2004.05.080",

language = "English",

volume = "60",

pages = "6597--6608",

journal = "Tetrahedron",

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publisher = "Elsevier Ltd.",

number = "31",

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T1 - Synthesis of peptidomimetics based on iminosugar and β-D- glucopyranoside scaffolds and inhibiton of HIV-protease

AU - Chery, Florence

AU - Cronin, Linda

AU - O'Brien, Julie L.

AU - Murphy, Paul V.

PY - 2004/7/26

Y1 - 2004/7/26

N2 - Synthetic routes to peptidomimetic compounds derived from saccharide scaffolds are described. The regioselective introduction of pivaloyl groups was achieved from N-benzyloxycarbonyl protected 1-deoxymannojirimycin or via D-fructopyranosides. The results from biological evaluation of the saccharide derivatives as HIV-protease inhibitors are included.

AB - Synthetic routes to peptidomimetic compounds derived from saccharide scaffolds are described. The regioselective introduction of pivaloyl groups was achieved from N-benzyloxycarbonyl protected 1-deoxymannojirimycin or via D-fructopyranosides. The results from biological evaluation of the saccharide derivatives as HIV-protease inhibitors are included.

KW - Azasugar

KW - Glucopyranoside

KW - HIV-protease

KW - Iminosugar

KW - Peptidomimetic

UR - https://www.scopus.com/pages/publications/4143087457

U2 - 10.1016/j.tet.2004.05.080

DO - 10.1016/j.tet.2004.05.080

M3 - Article

AN - SCOPUS:4143087457

SN - 0040-4020

VL - 60

SP - 6597

EP - 6608

JO - Tetrahedron

JF - Tetrahedron

IS - 31

ER -

Synthesis of peptidomimetics based on iminosugar and β-D- glucopyranoside scaffolds and inhibiton of HIV-protease

Abstract

UN SDGs

Keywords

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