Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds

Paul V. Murphy; Julie L. O'Brien; Lorraine J. Gorey-Feret; Amos B. Smith

doi:10.1016/S0040-4020(03)00208-4

Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds

Paul V. Murphy, Julie L. O'Brien, Lorraine J. Gorey-Feret, Amos B. Smith

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of peptidomimetic inhibitors of HIV-1 protease based on 6-deoxy-6-amino-β-D-glucopyranoside and 6-deoxy-6-amino-β-D-mannopyranoside scaffolds has been achieved. The inhibitors had IC₅₀ values in the micromolar range. The results provide a platform for the development of more potent carbohydrate based inhibitors of HIV-1 and other aspartic proteases.

Original language	English
Pages (from-to)	2259-2271
Number of pages	13
Journal	Tetrahedron
Volume	59
Issue number	13
DOIs	https://doi.org/10.1016/S0040-4020(03)00208-4
Publication status	Published - 24 Mar 2003
Externally published	Yes

Keywords

Aspartic acid
Carbohydrate based peptidomimetics
HIV-1
Inhibitors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0040-4020(03)00208-4

Cite this

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title = "Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds",

abstract = "The synthesis of peptidomimetic inhibitors of HIV-1 protease based on 6-deoxy-6-amino-β-D-glucopyranoside and 6-deoxy-6-amino-β-D-mannopyranoside scaffolds has been achieved. The inhibitors had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate based inhibitors of HIV-1 and other aspartic proteases.",

keywords = "Aspartic acid, Carbohydrate based peptidomimetics, HIV-1, Inhibitors",

author = "Murphy, \{Paul V.\} and O'Brien, \{Julie L.\} and Gorey-Feret, \{Lorraine J.\} and Smith, \{Amos B.\}",

year = "2003",

month = mar,

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doi = "10.1016/S0040-4020(03)00208-4",

language = "English",

volume = "59",

pages = "2259--2271",

journal = "Tetrahedron",

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number = "13",

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TY - JOUR

T1 - Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds

AU - Murphy, Paul V.

AU - O'Brien, Julie L.

AU - Gorey-Feret, Lorraine J.

AU - Smith, Amos B.

PY - 2003/3/24

Y1 - 2003/3/24

N2 - The synthesis of peptidomimetic inhibitors of HIV-1 protease based on 6-deoxy-6-amino-β-D-glucopyranoside and 6-deoxy-6-amino-β-D-mannopyranoside scaffolds has been achieved. The inhibitors had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate based inhibitors of HIV-1 and other aspartic proteases.

AB - The synthesis of peptidomimetic inhibitors of HIV-1 protease based on 6-deoxy-6-amino-β-D-glucopyranoside and 6-deoxy-6-amino-β-D-mannopyranoside scaffolds has been achieved. The inhibitors had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate based inhibitors of HIV-1 and other aspartic proteases.

KW - Aspartic acid

KW - Carbohydrate based peptidomimetics

KW - HIV-1

KW - Inhibitors

UR - https://www.scopus.com/pages/publications/0037463815

U2 - 10.1016/S0040-4020(03)00208-4

DO - 10.1016/S0040-4020(03)00208-4

M3 - Article

AN - SCOPUS:0037463815

SN - 0040-4020

VL - 59

SP - 2259

EP - 2271

JO - Tetrahedron

JF - Tetrahedron

IS - 13

ER -

Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds

Abstract

Keywords

UN SDGs

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