Synthesis, characterisation and photo-stability of a folate-modified β-cyclodextrin as a functional food additive

Zlata Tofzikovskaya; Christine O'Connor; Mary McNamara

doi:10.1007/s10847-012-0139-3

Synthesis, characterisation and photo-stability of a folate-modified β-cyclodextrin as a functional food additive

Zlata Tofzikovskaya, Christine O'Connor, Mary McNamara

Research output: Contribution to journal › Article › peer-review

Abstract

A novel two-step synthetic route was developed and gave the mono-substituted derivative 6-deoxy-6-[(1-(2-amino)ethylamino)folate]-β- cyclodextrin (CDEnFA) with high yield (60 %). Elemental analysis, mass spectrometry, ¹H and ¹³C NMR, FTIR and Raman spectroscopies demonstrated the successful synthesis of the γ isomer only with no evidence of the presence of other isomers or free folic acid. Electronic absorption spectroscopy was used to study the photochemical properties of CDEnFA and showed that in both the solid state and aqueous solution CDEnFA is considerably more photo-stable than free folic acid.

Original language	English
Pages (from-to)	437-445
Number of pages	9
Journal	Journal of Inclusion Phenomena and Macrocyclic Chemistry
Volume	74
Issue number	1-4
DOIs	https://doi.org/10.1007/s10847-012-0139-3
Publication status	Published - Dec 2012

Keywords

Cyclodextrin
Folate
Photo-stability

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10.1007/s10847-012-0139-3

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title = "Synthesis, characterisation and photo-stability of a folate-modified β-cyclodextrin as a functional food additive",

abstract = "A novel two-step synthetic route was developed and gave the mono-substituted derivative 6-deoxy-6-[(1-(2-amino)ethylamino)folate]-β- cyclodextrin (CDEnFA) with high yield (60 \%). Elemental analysis, mass spectrometry, 1H and 13C NMR, FTIR and Raman spectroscopies demonstrated the successful synthesis of the γ isomer only with no evidence of the presence of other isomers or free folic acid. Electronic absorption spectroscopy was used to study the photochemical properties of CDEnFA and showed that in both the solid state and aqueous solution CDEnFA is considerably more photo-stable than free folic acid.",

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T1 - Synthesis, characterisation and photo-stability of a folate-modified β-cyclodextrin as a functional food additive

AU - Tofzikovskaya, Zlata

AU - O'Connor, Christine

AU - McNamara, Mary

PY - 2012/12

Y1 - 2012/12

N2 - A novel two-step synthetic route was developed and gave the mono-substituted derivative 6-deoxy-6-[(1-(2-amino)ethylamino)folate]-β- cyclodextrin (CDEnFA) with high yield (60 %). Elemental analysis, mass spectrometry, 1H and 13C NMR, FTIR and Raman spectroscopies demonstrated the successful synthesis of the γ isomer only with no evidence of the presence of other isomers or free folic acid. Electronic absorption spectroscopy was used to study the photochemical properties of CDEnFA and showed that in both the solid state and aqueous solution CDEnFA is considerably more photo-stable than free folic acid.

AB - A novel two-step synthetic route was developed and gave the mono-substituted derivative 6-deoxy-6-[(1-(2-amino)ethylamino)folate]-β- cyclodextrin (CDEnFA) with high yield (60 %). Elemental analysis, mass spectrometry, 1H and 13C NMR, FTIR and Raman spectroscopies demonstrated the successful synthesis of the γ isomer only with no evidence of the presence of other isomers or free folic acid. Electronic absorption spectroscopy was used to study the photochemical properties of CDEnFA and showed that in both the solid state and aqueous solution CDEnFA is considerably more photo-stable than free folic acid.

KW - Cyclodextrin

KW - Folate

KW - Photo-stability

UR - https://www.scopus.com/pages/publications/84864419235

U2 - 10.1007/s10847-012-0139-3

DO - 10.1007/s10847-012-0139-3

M3 - Article

AN - SCOPUS:84864419235

SN - 0923-0750

VL - 74

SP - 437

EP - 445

JO - Journal of Inclusion Phenomena and Macrocyclic Chemistry

JF - Journal of Inclusion Phenomena and Macrocyclic Chemistry

IS - 1-4

ER -

Synthesis, characterisation and photo-stability of a folate-modified β-cyclodextrin as a functional food additive

Abstract

Keywords

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