Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ...

Michael Devereux; Denis O'Shea; Mark O'Connor; Helen Grehan; Gavin Connor; Malachy McCann; Georgina Rosair; Fiona Lyng; Andrew Kellett; Maureen Walsh; Denise Egan; Bhumika Thati

doi:10.1016/j.poly.2007.05.006

Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ...

Michael Devereux, Denis O'Shea, Mark O'Connor, Helen Grehan, Gavin Connor, Malachy McCann, Georgina Rosair, Fiona Lyng, Andrew Kellett, Maureen Walsh, Denise Egan, Bhumika Thati

Research output: Contribution to journal › Article › peer-review

135 Citations (Scopus)

Abstract

A series of simple Cu(II) carboxylate complexes {carboxylate = acetate (CH₃COO), salicylate (salH) or benzoate (BZA)}, some containing either one chelating {1,10-phenanthroline (phen) or 2,2′-bipyridine (bipy)} or two monodentate {benzimidazole (BZDH) or 5,6-dimethylbenzimidazole (5,6-DMBZDH)} nitrogen donor ligands, have been prepared and characterised. X-ray crystal structures have been determined for the square pyramidal complex [Cu(BZA)₂(bipy)(H₂O)] and the two square planar complexes [Cu(CH₃COO)₂ (5,6-DMBZDH)₂] and [Cu(salH)₂(BZDH)₂]. All of the complexes are poor catalase mimics in the presence of imidazole and totally inactive in its absence. The complexes all exhibit excellent superoxide dismutase (SOD) mimetic activity and the two phen derivatives [Cu(CH₃COO)₂(phen)] and [Cu(sal)(phen)] display potent in vitro cytotoxicity against human hepatic (Hep-G), renal (A-498) and lung (A-549) cancer cell lines.

Original language	English
Pages (from-to)	4073-4084
Number of pages	12
Journal	Polyhedron
Volume	26
Issue number	15
DOIs	https://doi.org/10.1016/j.poly.2007.05.006
Publication status	Published - 20 Sep 2007

Keywords

1,10-Phenanthroline
2,2′-Bipyridine
Benzimidazole
Catalase
Copper(II)carboxylates
SOD and anticancer activity

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10.1016/j.poly.2007.05.006

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Devereux, M., O'Shea, D., O'Connor, M., Grehan, H., Connor, G., McCann, M., Rosair, G., Lyng, F., Kellett, A., Walsh, M., Egan, D., & Thati, B. (2007). Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ... Polyhedron, 26(15), 4073-4084. https://doi.org/10.1016/j.poly.2007.05.006

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title = "Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ...",

abstract = "A series of simple Cu(II) carboxylate complexes {carboxylate = acetate (CH3COO), salicylate (salH) or benzoate (BZA)}, some containing either one chelating {1,10-phenanthroline (phen) or 2,2′-bipyridine (bipy)} or two monodentate {benzimidazole (BZDH) or 5,6-dimethylbenzimidazole (5,6-DMBZDH)} nitrogen donor ligands, have been prepared and characterised. X-ray crystal structures have been determined for the square pyramidal complex [Cu(BZA)2(bipy)(H2O)] and the two square planar complexes [Cu(CH3COO)2 (5,6-DMBZDH)2] and [Cu(salH)2(BZDH)2]. All of the complexes are poor catalase mimics in the presence of imidazole and totally inactive in its absence. The complexes all exhibit excellent superoxide dismutase (SOD) mimetic activity and the two phen derivatives [Cu(CH3COO)2(phen)] and [Cu(sal)(phen)] display potent in vitro cytotoxicity against human hepatic (Hep-G), renal (A-498) and lung (A-549) cancer cell lines.",

keywords = "1,10-Phenanthroline, 2,2′-Bipyridine, Benzimidazole, Catalase, Copper(II)carboxylates, SOD and anticancer activity",

author = "Michael Devereux and Denis O'Shea and Mark O'Connor and Helen Grehan and Gavin Connor and Malachy McCann and Georgina Rosair and Fiona Lyng and Andrew Kellett and Maureen Walsh and Denise Egan and Bhumika Thati",

note = "Funding Information: M.O.C. acknowledges Irish Technological Sector Research Strand I programme 2002 (Project No. PT03147). The authors also acknowledge funding received through the Irish Technological Sector Research Strand III programme 2002 (Project No. CRS02-TA01) and DIT Team Research Scheme (TERS) funding for Interdisciplinary Cancer Research. This work has been carried out (in part) within the structures of the Facility for Optical Characterisation and Spectroscopy (now the FOCAS Institute, DIT), funded under The Irish National Development Plan 2000–2006 with assistance from the European Regional Development Fund.",

year = "2007",

month = sep,

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doi = "10.1016/j.poly.2007.05.006",

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Devereux, M, O'Shea, D, O'Connor, M, Grehan, H, Connor, G, McCann, M, Rosair, G, Lyng, F, Kellett, A, Walsh, M, Egan, D & Thati, B 2007, 'Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ...', Polyhedron, vol. 26, no. 15, pp. 4073-4084. https://doi.org/10.1016/j.poly.2007.05.006

TY - JOUR

T1 - Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands

T2 - ...

AU - Devereux, Michael

AU - O'Shea, Denis

AU - O'Connor, Mark

AU - Grehan, Helen

AU - Connor, Gavin

AU - McCann, Malachy

AU - Rosair, Georgina

AU - Lyng, Fiona

AU - Kellett, Andrew

AU - Walsh, Maureen

AU - Egan, Denise

AU - Thati, Bhumika

N1 - Funding Information: M.O.C. acknowledges Irish Technological Sector Research Strand I programme 2002 (Project No. PT03147). The authors also acknowledge funding received through the Irish Technological Sector Research Strand III programme 2002 (Project No. CRS02-TA01) and DIT Team Research Scheme (TERS) funding for Interdisciplinary Cancer Research. This work has been carried out (in part) within the structures of the Facility for Optical Characterisation and Spectroscopy (now the FOCAS Institute, DIT), funded under The Irish National Development Plan 2000–2006 with assistance from the European Regional Development Fund.

PY - 2007/9/20

Y1 - 2007/9/20

N2 - A series of simple Cu(II) carboxylate complexes {carboxylate = acetate (CH3COO), salicylate (salH) or benzoate (BZA)}, some containing either one chelating {1,10-phenanthroline (phen) or 2,2′-bipyridine (bipy)} or two monodentate {benzimidazole (BZDH) or 5,6-dimethylbenzimidazole (5,6-DMBZDH)} nitrogen donor ligands, have been prepared and characterised. X-ray crystal structures have been determined for the square pyramidal complex [Cu(BZA)2(bipy)(H2O)] and the two square planar complexes [Cu(CH3COO)2 (5,6-DMBZDH)2] and [Cu(salH)2(BZDH)2]. All of the complexes are poor catalase mimics in the presence of imidazole and totally inactive in its absence. The complexes all exhibit excellent superoxide dismutase (SOD) mimetic activity and the two phen derivatives [Cu(CH3COO)2(phen)] and [Cu(sal)(phen)] display potent in vitro cytotoxicity against human hepatic (Hep-G), renal (A-498) and lung (A-549) cancer cell lines.

AB - A series of simple Cu(II) carboxylate complexes {carboxylate = acetate (CH3COO), salicylate (salH) or benzoate (BZA)}, some containing either one chelating {1,10-phenanthroline (phen) or 2,2′-bipyridine (bipy)} or two monodentate {benzimidazole (BZDH) or 5,6-dimethylbenzimidazole (5,6-DMBZDH)} nitrogen donor ligands, have been prepared and characterised. X-ray crystal structures have been determined for the square pyramidal complex [Cu(BZA)2(bipy)(H2O)] and the two square planar complexes [Cu(CH3COO)2 (5,6-DMBZDH)2] and [Cu(salH)2(BZDH)2]. All of the complexes are poor catalase mimics in the presence of imidazole and totally inactive in its absence. The complexes all exhibit excellent superoxide dismutase (SOD) mimetic activity and the two phen derivatives [Cu(CH3COO)2(phen)] and [Cu(sal)(phen)] display potent in vitro cytotoxicity against human hepatic (Hep-G), renal (A-498) and lung (A-549) cancer cell lines.

KW - 1,10-Phenanthroline

KW - 2,2′-Bipyridine

KW - Benzimidazole

KW - Catalase

KW - Copper(II)carboxylates

KW - SOD and anticancer activity

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U2 - 10.1016/j.poly.2007.05.006

DO - 10.1016/j.poly.2007.05.006

M3 - Article

AN - SCOPUS:34548363729

SN - 0277-5387

VL - 26

SP - 4073

EP - 4084

JO - Polyhedron

JF - Polyhedron

IS - 15

ER -

Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: ...

Abstract

Keywords

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