Synergistic cytotoxicity from cold atmospheric plasma and ultrasound in glioma cells

Andressa M. Aguiar de Carvalho; Laurence Scally; Brijesh Tiwari; Patrick J. Cullen; James F. Curtin

doi:10.1002/ppap.202200042

Synergistic cytotoxicity from cold atmospheric plasma and ultrasound in glioma cells

Andressa M. Aguiar de Carvalho, Laurence Scally, Brijesh Tiwari, Patrick J. Cullen, James F. Curtin

Research output: Contribution to journal › Article › peer-review

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Abstract

The aim of this study was to investigate whether sonoporation of cancer cells using ultrasound (US) technology could enhance the anticancer effects of cold atmospheric plasma. US-induced transient sonoporation of cancer cells with little to no cytotoxicity observed on the cell lines tested. Synergistic effects of US were observed when combined with both direct and indirect cold atmospheric plasma. These cytotoxic effects were dependent on reactive species production. To the best of our knowledge that is the first time that the effects of those two nonthermal technologies were evaluated in cancer cells, demonstrating a promising combined strategy for cancer therapies, particularly for those with penetration limitations, such as glioblastoma.

Original language	English
Article number	2200042
Journal	Plasma Processes and Polymers
Volume	19
Issue number	8
DOIs	https://doi.org/10.1002/ppap.202200042
Publication status	Published - Aug 2022

Keywords

cavitation
glioblastoma
nonthermal plasma
plasma
sonoporation

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title = "Synergistic cytotoxicity from cold atmospheric plasma and ultrasound in glioma cells",

abstract = "The aim of this study was to investigate whether sonoporation of cancer cells using ultrasound (US) technology could enhance the anticancer effects of cold atmospheric plasma. US-induced transient sonoporation of cancer cells with little to no cytotoxicity observed on the cell lines tested. Synergistic effects of US were observed when combined with both direct and indirect cold atmospheric plasma. These cytotoxic effects were dependent on reactive species production. To the best of our knowledge that is the first time that the effects of those two nonthermal technologies were evaluated in cancer cells, demonstrating a promising combined strategy for cancer therapies, particularly for those with penetration limitations, such as glioblastoma.",

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author = "{Aguiar de Carvalho}, {Andressa M.} and Laurence Scally and Brijesh Tiwari and Cullen, {Patrick J.} and Curtin, {James F.}",

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AU - Aguiar de Carvalho, Andressa M.

AU - Scally, Laurence

AU - Tiwari, Brijesh

AU - Cullen, Patrick J.

AU - Curtin, James F.

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N2 - The aim of this study was to investigate whether sonoporation of cancer cells using ultrasound (US) technology could enhance the anticancer effects of cold atmospheric plasma. US-induced transient sonoporation of cancer cells with little to no cytotoxicity observed on the cell lines tested. Synergistic effects of US were observed when combined with both direct and indirect cold atmospheric plasma. These cytotoxic effects were dependent on reactive species production. To the best of our knowledge that is the first time that the effects of those two nonthermal technologies were evaluated in cancer cells, demonstrating a promising combined strategy for cancer therapies, particularly for those with penetration limitations, such as glioblastoma.

AB - The aim of this study was to investigate whether sonoporation of cancer cells using ultrasound (US) technology could enhance the anticancer effects of cold atmospheric plasma. US-induced transient sonoporation of cancer cells with little to no cytotoxicity observed on the cell lines tested. Synergistic effects of US were observed when combined with both direct and indirect cold atmospheric plasma. These cytotoxic effects were dependent on reactive species production. To the best of our knowledge that is the first time that the effects of those two nonthermal technologies were evaluated in cancer cells, demonstrating a promising combined strategy for cancer therapies, particularly for those with penetration limitations, such as glioblastoma.

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KW - glioblastoma

KW - nonthermal plasma

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KW - sonoporation

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Synergistic cytotoxicity from cold atmospheric plasma and ultrasound in glioma cells

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Keywords

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