Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(iii) glycoconjugate systems

Karolina Wojtczak; Eva Zahorska; Ian J. Murphy; Finnja Koppel; Gordon Cooke; Alexander Titz; Joseph P. Byrne

doi:10.1039/d3cc02300a

Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(iii) glycoconjugate systems

Karolina Wojtczak, Eva Zahorska, Ian J. Murphy, Finnja Koppel, Gordon Cooke, Alexander Titz, Joseph P. Byrne

Research output: Contribution to journal › Article › peer-review

Abstract

Interactions of lectins with glycoconjugate-terbium(iii) self-assembly complexes lead to sensing through enhanced lanthanide luminescence. This glycan-directed sensing paradigm detects an unlabelled lectin (LecA) associated with pathogen P. aeruginosa in solution, without any bactericidal activity. Further development of these probes could have potential as a diagnostic tool.

Original language	English
Pages (from-to)	8384-8387
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	54
DOIs	https://doi.org/10.1039/d3cc02300a
Publication status	Published - 8 Jun 2023

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https://arrow.tudublin.ie/scschcpsart/142Licence: CC BY-NC-SA

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title = "Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(iii) glycoconjugate systems",

abstract = "Interactions of lectins with glycoconjugate-terbium(iii) self-assembly complexes lead to sensing through enhanced lanthanide luminescence. This glycan-directed sensing paradigm detects an unlabelled lectin (LecA) associated with pathogen P. aeruginosa in solution, without any bactericidal activity. Further development of these probes could have potential as a diagnostic tool.",

author = "Karolina Wojtczak and Eva Zahorska and Murphy, {Ian J.} and Finnja Koppel and Gordon Cooke and Alexander Titz and Byrne, {Joseph P.}",

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AU - Wojtczak, Karolina

AU - Zahorska, Eva

AU - Murphy, Ian J.

AU - Koppel, Finnja

AU - Cooke, Gordon

AU - Titz, Alexander

AU - Byrne, Joseph P.

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Y1 - 2023/6/8

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AB - Interactions of lectins with glycoconjugate-terbium(iii) self-assembly complexes lead to sensing through enhanced lanthanide luminescence. This glycan-directed sensing paradigm detects an unlabelled lectin (LecA) associated with pathogen P. aeruginosa in solution, without any bactericidal activity. Further development of these probes could have potential as a diagnostic tool.

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SP - 8384

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JO - Chemical Communications

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Switch-on luminescent sensing of unlabelled bacterial lectin by terbium(iii) glycoconjugate systems

Abstract

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