Structure-based design and synthesis of HIV-1 protease inhibitors employing β-D-mannopyranoside scaffolds

Biochemistry, Genetics and Molecular Biology

• Protease Inhibitor 100%
• HIV-1 Protease 100%
• IC50 50%
• Protease 50%
• Human Immunodeficiency Virus 1 50%
• Peptidomimetic 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Proteinase Inhibitor 100%
• Human Immunodeficiency Virus Proteinase 100%
• IC50 50%
• Aspartic Proteinase 50%
• HIV 50%
• Peptidomimetics 50%

Chemistry

• IC50 100%
• Peptidomimetic 100%