Structure-based design and synthesis of HIV-1 protease inhibitors employing β-D-mannopyranoside scaffolds

Paul V. Murphy; Julie L. O'Brien; Lorraine J. Gorey-Feret; Amos B. Smith

doi:10.1016/S0960-894X(02)00220-2

Structure-based design and synthesis of HIV-1 protease inhibitors employing β-D-mannopyranoside scaffolds

Paul V. Murphy, Julie L. O'Brien, Lorraine J. Gorey-Feret, Amos B. Smith

Research output: Contribution to journal › Article › peer-review

Abstract

A preliminary account on the structure-based design, synthesis and evaluation of peptidomimetic inhibitors of HIV-1 protease containing β-D-mannopyranoside scaffolds is given. The compounds prepared had IC₅₀ values in the micromolar range. The results provide a platform for the development of more potent carbohydrate-based inhibitors of HIV-1 and other aspartic proteases.

Original language	English
Pages (from-to)	1763-1766
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	13
DOIs	https://doi.org/10.1016/S0960-894X(02)00220-2
Publication status	Published - 8 Jul 2002
Externally published	Yes

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10.1016/S0960-894X(02)00220-2

Cite this

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title = "Structure-based design and synthesis of HIV-1 protease inhibitors employing β-D-mannopyranoside scaffolds",

abstract = "A preliminary account on the structure-based design, synthesis and evaluation of peptidomimetic inhibitors of HIV-1 protease containing β-D-mannopyranoside scaffolds is given. The compounds prepared had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate-based inhibitors of HIV-1 and other aspartic proteases.",

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AU - Gorey-Feret, Lorraine J.

AU - Smith, Amos B.

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AB - A preliminary account on the structure-based design, synthesis and evaluation of peptidomimetic inhibitors of HIV-1 protease containing β-D-mannopyranoside scaffolds is given. The compounds prepared had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate-based inhibitors of HIV-1 and other aspartic proteases.

UR - https://www.scopus.com/pages/publications/0037042775

U2 - 10.1016/S0960-894X(02)00220-2

DO - 10.1016/S0960-894X(02)00220-2

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JO - Bioorganic and Medicinal Chemistry Letters

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IS - 13

ER -

Structure-based design and synthesis of HIV-1 protease inhibitors employing β-D-mannopyranoside scaffolds

Abstract

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