Stratifying Ischaemic Stroke Patients Across 3 Treatment Windows Using T2 Relaxation Times, Ordinal Regression and Cumulative Probabilities

Bryony McGarry; Elizabeth Hunter; Robin Damian; Michael Knight; Philip Clatworthy; George Harston; Keith Muir; Risto Kauppinen; John Kelleher

doi:10.21427/xcde-4c10

Stratifying Ischaemic Stroke Patients Across 3 Treatment Windows Using T2 Relaxation Times, Ordinal Regression and Cumulative Probabilities

Bryony McGarry, Elizabeth Hunter, Robin Damian, Michael Knight, Philip Clatworthy, George Harston, Keith Muir, Risto Kauppinen, John Kelleher

Research output: Contribution to conference › Paper › peer-review

Abstract

Unknown onset time is a common contraindication for anti-thrombolytic treatment of ischaemic stroke. T2 relaxation-based signal changes within the lesion can identify patients within or beyond the 4.5-hour intravenous thrombolysis treatment-window. However, now that intra-arterial thrombolysis is recommended between 4.5 and 6 hours from symptom onset and mechanical thrombectomy is considered safe between 6 and 24 hours, there are three treatment-windows to consider. Here we show a cumulative ordinal regression model, incorporating the T2 relaxation time, predicts the probabilities of a patient being within one of the three treatment-windows and is more accurate than signal intensity changes from T2 weighted images.

Original language	English
DOIs	https://doi.org/10.21427/xcde-4c10
Publication status	Published - 2021
Event	International Society of Magnetic Resonance in Medicine (ISMRM) Annual Conference - Duration: 1 Jan 2021 → …

Conference

Conference	International Society of Magnetic Resonance in Medicine (ISMRM) Annual Conference
Period	1/01/21 → …

Keywords

Unknown onset time
anti-thrombolytic treatment
ischaemic stroke
T2 relaxation-based signal changes
intravenous thrombolysis
intra-arterial thrombolysis
mechanical thrombectomy
treatment-windows
cumulative ordinal regression model
T2 relaxation time
signal intensity changes
T2 weighted images

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10.21427/xcde-4c10Licence: CC BY-NC-SA

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McGarry, B., Hunter, E., Damian, R., Knight, M., Clatworthy, P., Harston, G., Muir, K., Kauppinen, R., & Kelleher, J. (2021). Stratifying Ischaemic Stroke Patients Across 3 Treatment Windows Using T2 Relaxation Times, Ordinal Regression and Cumulative Probabilities. Paper presented at International Society of Magnetic Resonance in Medicine (ISMRM) Annual Conference. https://doi.org/10.21427/xcde-4c10

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title = "Stratifying Ischaemic Stroke Patients Across 3 Treatment Windows Using T2 Relaxation Times, Ordinal Regression and Cumulative Probabilities",

abstract = "Unknown onset time is a common contraindication for anti-thrombolytic treatment of ischaemic stroke. T2 relaxation-based signal changes within the lesion can identify patients within or beyond the 4.5-hour intravenous thrombolysis treatment-window. However, now that intra-arterial thrombolysis is recommended between 4.5 and 6 hours from symptom onset and mechanical thrombectomy is considered safe between 6 and 24 hours, there are three treatment-windows to consider. Here we show a cumulative ordinal regression model, incorporating the T2 relaxation time, predicts the probabilities of a patient being within one of the three treatment-windows and is more accurate than signal intensity changes from T2 weighted images.",

keywords = "Unknown onset time, anti-thrombolytic treatment, ischaemic stroke, T2 relaxation-based signal changes, intravenous thrombolysis, intra-arterial thrombolysis, mechanical thrombectomy, treatment-windows, cumulative ordinal regression model, T2 relaxation time, signal intensity changes, T2 weighted images",

author = "Bryony McGarry and Elizabeth Hunter and Robin Damian and Michael Knight and Philip Clatworthy and George Harston and Keith Muir and Risto Kauppinen and John Kelleher",

year = "2021",

doi = "10.21427/xcde-4c10",

language = "English",

note = "International Society of Magnetic Resonance in Medicine (ISMRM) Annual Conference ; Conference date: 01-01-2021",

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McGarry, B, Hunter, E, Damian, R, Knight, M, Clatworthy, P, Harston, G, Muir, K, Kauppinen, R & Kelleher, J 2021, 'Stratifying Ischaemic Stroke Patients Across 3 Treatment Windows Using T2 Relaxation Times, Ordinal Regression and Cumulative Probabilities', Paper presented at International Society of Magnetic Resonance in Medicine (ISMRM) Annual Conference, 1/01/21. https://doi.org/10.21427/xcde-4c10

Stratifying Ischaemic Stroke Patients Across 3 Treatment Windows Using T2 Relaxation Times, Ordinal Regression and Cumulative Probabilities. / McGarry, Bryony; Hunter, Elizabeth; Damian, Robin et al.
2021. Paper presented at International Society of Magnetic Resonance in Medicine (ISMRM) Annual Conference.

Research output: Contribution to conference › Paper › peer-review

TY - CONF

T1 - Stratifying Ischaemic Stroke Patients Across 3 Treatment Windows Using T2 Relaxation Times, Ordinal Regression and Cumulative Probabilities

AU - McGarry, Bryony

AU - Hunter, Elizabeth

AU - Damian, Robin

AU - Knight, Michael

AU - Clatworthy, Philip

AU - Harston, George

AU - Muir, Keith

AU - Kauppinen, Risto

AU - Kelleher, John

PY - 2021

Y1 - 2021

N2 - Unknown onset time is a common contraindication for anti-thrombolytic treatment of ischaemic stroke. T2 relaxation-based signal changes within the lesion can identify patients within or beyond the 4.5-hour intravenous thrombolysis treatment-window. However, now that intra-arterial thrombolysis is recommended between 4.5 and 6 hours from symptom onset and mechanical thrombectomy is considered safe between 6 and 24 hours, there are three treatment-windows to consider. Here we show a cumulative ordinal regression model, incorporating the T2 relaxation time, predicts the probabilities of a patient being within one of the three treatment-windows and is more accurate than signal intensity changes from T2 weighted images.

AB - Unknown onset time is a common contraindication for anti-thrombolytic treatment of ischaemic stroke. T2 relaxation-based signal changes within the lesion can identify patients within or beyond the 4.5-hour intravenous thrombolysis treatment-window. However, now that intra-arterial thrombolysis is recommended between 4.5 and 6 hours from symptom onset and mechanical thrombectomy is considered safe between 6 and 24 hours, there are three treatment-windows to consider. Here we show a cumulative ordinal regression model, incorporating the T2 relaxation time, predicts the probabilities of a patient being within one of the three treatment-windows and is more accurate than signal intensity changes from T2 weighted images.

KW - Unknown onset time

KW - anti-thrombolytic treatment

KW - ischaemic stroke

KW - T2 relaxation-based signal changes

KW - intravenous thrombolysis

KW - intra-arterial thrombolysis

KW - mechanical thrombectomy

KW - treatment-windows

KW - cumulative ordinal regression model

KW - T2 relaxation time

KW - signal intensity changes

KW - T2 weighted images

U2 - 10.21427/xcde-4c10

DO - 10.21427/xcde-4c10

M3 - Paper

T2 - International Society of Magnetic Resonance in Medicine (ISMRM) Annual Conference

Y2 - 1 January 2021

ER -

Stratifying Ischaemic Stroke Patients Across 3 Treatment Windows Using T2 Relaxation Times, Ordinal Regression and Cumulative Probabilities

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Keywords

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