Spirocyclic NK1 antagonists I: [4.5] and [5.5]-Spiroketals

Eileen M. Seward; Emma Carlson; Timothy Harrison; Karen E. Haworth; Richard Herbert; Fintan J. Kelleher; Marc M. Kurtz; Jonathan Moseley; Simon N. Owen; Andrew P. Owens; Sharon J. Sadowski; Christopher J. Swain; Brian J. Williams

doi:10.1016/S0960-894X(02)00506-1

Spirocyclic NK₁ antagonists I: [4.5] and [5.5]-Spiroketals

Eileen M. Seward, Emma Carlson, Timothy Harrison, Karen E. Haworth, Richard Herbert, Fintan J. Kelleher, Marc M. Kurtz, Jonathan Moseley, Simon N. Owen, Andrew P. Owens, Sharon J. Sadowski, Christopher J. Swain, Brian J. Williams

Research output: Contribution to journal › Article › peer-review

Abstract

A series of novel spiroketal-based NK₁ antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.

Original language	English
Pages (from-to)	2515-2518
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	12
Issue number	18
DOIs	https://doi.org/10.1016/S0960-894X(02)00506-1
Publication status	Published - 16 Sep 2002
Externally published	Yes

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10.1016/S0960-894X(02)00506-1

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@article{a4285eab7b3d42e39d278ec3bab02557,

title = "Spirocyclic NK1 antagonists I: [4.5] and [5.5]-Spiroketals",

abstract = "A series of novel spiroketal-based NK1 antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.",

author = "Seward, \{Eileen M.\} and Emma Carlson and Timothy Harrison and Haworth, \{Karen E.\} and Richard Herbert and Kelleher, \{Fintan J.\} and Kurtz, \{Marc M.\} and Jonathan Moseley and Owen, \{Simon N.\} and Owens, \{Andrew P.\} and Sadowski, \{Sharon J.\} and Swain, \{Christopher J.\} and Williams, \{Brian J.\}",

year = "2002",

month = sep,

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doi = "10.1016/S0960-894X(02)00506-1",

language = "English",

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pages = "2515--2518",

journal = "Bioorganic and Medicinal Chemistry Letters",

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publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Spirocyclic NK1 antagonists I

T2 - [4.5] and [5.5]-Spiroketals

AU - Seward, Eileen M.

AU - Carlson, Emma

AU - Harrison, Timothy

AU - Haworth, Karen E.

AU - Herbert, Richard

AU - Kelleher, Fintan J.

AU - Kurtz, Marc M.

AU - Moseley, Jonathan

AU - Owen, Simon N.

AU - Owens, Andrew P.

AU - Sadowski, Sharon J.

AU - Swain, Christopher J.

AU - Williams, Brian J.

PY - 2002/9/16

Y1 - 2002/9/16

N2 - A series of novel spiroketal-based NK1 antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.

AB - A series of novel spiroketal-based NK1 antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.

UR - https://www.scopus.com/pages/publications/18644380514

U2 - 10.1016/S0960-894X(02)00506-1

DO - 10.1016/S0960-894X(02)00506-1

M3 - Article

C2 - 12182850

AN - SCOPUS:18644380514

SN - 0960-894X

VL - 12

SP - 2515

EP - 2518

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 18

ER -

Spirocyclic NK1 antagonists I: [4.5] and [5.5]-Spiroketals

Abstract

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Spirocyclic NK₁ antagonists I: [4.5] and [5.5]-Spiroketals