@article{6d0dd4e199e2484d83c06860bf549f58,
title = "Spirobicyclic diamines 1: synthesis of proline-derived spirolactams via thermal intramolecular ester aminolysis",
abstract = "Proline-derived [4.4]-spirolactams have been synthesised in good yields by a reductive-amination reaction followed by thermal cyclisation of the resulting amine onto the proline ester group in refluxing toluene. The synthesis of the corresponding [4.5]-spirolactams by the same method gave much reduced yields.",
author = "Fintan Kelleher and Sinead Kelly",
note = "Funding Information: We thank Dr. Brian Murray for help with NMR spectroscopy and useful discussions. We are grateful to Strand III of the Irish Government{\textquoteright}s National Development Plan (2000–2006) Technological Sector Research Program, through the Council of Directors of the Institutes of Technology, for funding for S.K. (Grant CRS/01/TA02).",
year = "2006",
month = may,
day = "1",
doi = "10.1016/j.tetlet.2006.03.021",
language = "English",
volume = "47",
pages = "3005--3008",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "18",
}