TY - JOUR
T1 - Silver(i) complexes of 9-anthracenecarboxylic acid and imidazoles
T2 - Synthesis, structure and antimicrobial activity
AU - McCann, Malachy
AU - Curran, Robert
AU - Ben-Shoshan, Marcia
AU - McKee, Vickie
AU - Tahir, Asif Ali
AU - Devereux, Michael
AU - Kavanagh, Kevin
AU - Creaven, Bernadette S.
AU - Kellett, Andrew
PY - 2012/6/7
Y1 - 2012/6/7
N2 - [Ag 2(9-aca) 2] (1) (9-acaH = 9-anthracenecarboxylic acid) reacts with a series of imidazoles to give [Ag(imidH) 2.3(CH 3CN) 0.7](9-aca) (3), [Ag 6(imidH) 4(9-aca) 6(MeOH) 2] (4), {[Ag(1-Me-imid) 2] 2[Ag 4(9-aca) 6]} (5), {[Ag(1-Bu-imid) 2] 2[Ag 4(9-aca) 6]} (6) and [Ag(apim)](9-aca)·H 2O (7) (imidH = imidazole; 1-Me-imid = 1-methylimidazole; 1-Bu-imid = 1-butylimidazole; apim = 1-(3-aminopropyl)imidazole). The mononuclear complex 3, hexanuclear 4-6, and polymeric 7, were all characterised using X-ray crystallography. While many of the complexes possess excellent in vitro antifungal and antibacterial activities they are, unanimously, more effective against fungal cells. The insect, Galleria mellonella, can survive high doses of the Ag(i) complexes administered in vivo, and a number of the complexes offer significant protection to larvae infected with a lethal dose of pathogenic Candida albicans cells.
AB - [Ag 2(9-aca) 2] (1) (9-acaH = 9-anthracenecarboxylic acid) reacts with a series of imidazoles to give [Ag(imidH) 2.3(CH 3CN) 0.7](9-aca) (3), [Ag 6(imidH) 4(9-aca) 6(MeOH) 2] (4), {[Ag(1-Me-imid) 2] 2[Ag 4(9-aca) 6]} (5), {[Ag(1-Bu-imid) 2] 2[Ag 4(9-aca) 6]} (6) and [Ag(apim)](9-aca)·H 2O (7) (imidH = imidazole; 1-Me-imid = 1-methylimidazole; 1-Bu-imid = 1-butylimidazole; apim = 1-(3-aminopropyl)imidazole). The mononuclear complex 3, hexanuclear 4-6, and polymeric 7, were all characterised using X-ray crystallography. While many of the complexes possess excellent in vitro antifungal and antibacterial activities they are, unanimously, more effective against fungal cells. The insect, Galleria mellonella, can survive high doses of the Ag(i) complexes administered in vivo, and a number of the complexes offer significant protection to larvae infected with a lethal dose of pathogenic Candida albicans cells.
UR - https://www.scopus.com/pages/publications/84862903238
U2 - 10.1039/c2dt12166b
DO - 10.1039/c2dt12166b
M3 - Article
C2 - 22476383
AN - SCOPUS:84862903238
SN - 1477-9226
VL - 41
SP - 6516
EP - 6527
JO - Dalton Transactions
JF - Dalton Transactions
IS - 21
ER -