Serine derived NK1 antagonists 1: The effect of modifications to the serine substituents

J. M. Elliott; M. A. Cascieri; G. Chicchi; S. Davies; F. J. Kelleher; M. Kurtz; T. Ladduwahetty; R. T. Lewis; A. M. MacLeod; K. J. Merchant; S. Sadowski; G. I. Stevenson

doi:10.1016/S0960-894X(98)00320-5

Serine derived NK₁ antagonists 1: The effect of modifications to the serine substituents

J. M. Elliott, M. A. Cascieri, G. Chicchi, S. Davies, F. J. Kelleher, M. Kurtz, T. Ladduwahetty, R. T. Lewis, A. M. MacLeod, K. J. Merchant, S. Sadowski, G. I. Stevenson

Research output: Contribution to journal › Article › peer-review

Abstract

A series of novel serine derived NK₁ antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.

Original language	English
Pages (from-to)	1845-1850
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(98)00320-5
Publication status	Published - 21 Jul 1998
Externally published	Yes

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10.1016/S0960-894X(98)00320-5

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Elliott, J. M., Cascieri, M. A., Chicchi, G., Davies, S., Kelleher, F. J., Kurtz, M., Ladduwahetty, T., Lewis, R. T., MacLeod, A. M., Merchant, K. J., Sadowski, S., & Stevenson, G. I. (1998). Serine derived NK₁ antagonists 1: The effect of modifications to the serine substituents. Bioorganic and Medicinal Chemistry Letters, 8(14), 1845-1850. https://doi.org/10.1016/S0960-894X(98)00320-5

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abstract = "A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.",

author = "Elliott, \{J. M.\} and Cascieri, \{M. A.\} and G. Chicchi and S. Davies and Kelleher, \{F. J.\} and M. Kurtz and T. Ladduwahetty and Lewis, \{R. T.\} and MacLeod, \{A. M.\} and Merchant, \{K. J.\} and S. Sadowski and Stevenson, \{G. I.\}",

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doi = "10.1016/S0960-894X(98)00320-5",

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Elliott, JM, Cascieri, MA, Chicchi, G, Davies, S, Kelleher, FJ, Kurtz, M, Ladduwahetty, T, Lewis, RT, MacLeod, AM, Merchant, KJ, Sadowski, S & Stevenson, GI 1998, 'Serine derived NK₁ antagonists 1: The effect of modifications to the serine substituents', Bioorganic and Medicinal Chemistry Letters, vol. 8, no. 14, pp. 1845-1850. https://doi.org/10.1016/S0960-894X(98)00320-5

TY - JOUR

T1 - Serine derived NK1 antagonists 1

T2 - The effect of modifications to the serine substituents

AU - Elliott, J. M.

AU - Cascieri, M. A.

AU - Chicchi, G.

AU - Davies, S.

AU - Kelleher, F. J.

AU - Kurtz, M.

AU - Ladduwahetty, T.

AU - Lewis, R. T.

AU - MacLeod, A. M.

AU - Merchant, K. J.

AU - Sadowski, S.

AU - Stevenson, G. I.

PY - 1998/7/21

Y1 - 1998/7/21

N2 - A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.

AB - A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.

UR - https://www.scopus.com/pages/publications/0032555069

U2 - 10.1016/S0960-894X(98)00320-5

DO - 10.1016/S0960-894X(98)00320-5

M3 - Article

C2 - 9873445

AN - SCOPUS:0032555069

SN - 0960-894X

VL - 8

SP - 1845

EP - 1850

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 14

ER -

Serine derived NK1 antagonists 1: The effect of modifications to the serine substituents

Abstract

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Serine derived NK₁ antagonists 1: The effect of modifications to the serine substituents