Serine derived NK1 antagonists 1: The effect of modifications to the serine substituents

J. M. Elliott; M. A. Cascieri; G. Chicchi; S. Davies; F. J. Kelleher; M. Kurtz; T. Ladduwahetty; R. T. Lewis; A. M. MacLeod; K. J. Merchant; S. Sadowski; G. I. Stevenson

doi:10.1016/S0960-894X(98)00320-5

Serine derived NK₁ antagonists 1: The effect of modifications to the serine substituents

J. M. Elliott
, M. A. Cascieri
, G. Chicchi
, S. Davies
, F. J. Kelleher
, M. Kurtz
, T. Ladduwahetty
, R. T. Lewis
, A. M. MacLeod
, K. J. Merchant
, S. Sadowski
, G. I. Stevenson

Research output: Contribution to journal › Article › peer-review

Abstract

A series of novel serine derived NK₁ antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.

Original language	English
Pages (from-to)	1845-1850
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	14
DOIs	https://doi.org/10.1016/S0960-894X(98)00320-5
Publication status	Published - 21 Jul 1998
Externally published	Yes

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10.1016/S0960-894X(98)00320-5

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Elliott, J. M., Cascieri, M. A., Chicchi, G., Davies, S., Kelleher, F. J., Kurtz, M., Ladduwahetty, T., Lewis, R. T., MacLeod, A. M., Merchant, K. J., Sadowski, S., & Stevenson, G. I. (1998). Serine derived NK₁ antagonists 1: The effect of modifications to the serine substituents. Bioorganic and Medicinal Chemistry Letters, 8(14), 1845-1850. https://doi.org/10.1016/S0960-894X(98)00320-5

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title = "Serine derived NK1 antagonists 1: The effect of modifications to the serine substituents",

abstract = "A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.",

author = "Elliott, \{J. M.\} and Cascieri, \{M. A.\} and G. Chicchi and S. Davies and Kelleher, \{F. J.\} and M. Kurtz and T. Ladduwahetty and Lewis, \{R. T.\} and MacLeod, \{A. M.\} and Merchant, \{K. J.\} and S. Sadowski and Stevenson, \{G. I.\}",

year = "1998",

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doi = "10.1016/S0960-894X(98)00320-5",

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pages = "1845--1850",

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Elliott, JM, Cascieri, MA, Chicchi, G, Davies, S, Kelleher, FJ, Kurtz, M, Ladduwahetty, T, Lewis, RT, MacLeod, AM, Merchant, KJ, Sadowski, S & Stevenson, GI 1998, 'Serine derived NK₁ antagonists 1: The effect of modifications to the serine substituents', Bioorganic and Medicinal Chemistry Letters, vol. 8, no. 14, pp. 1845-1850. https://doi.org/10.1016/S0960-894X(98)00320-5

TY - JOUR

T1 - Serine derived NK1 antagonists 1

T2 - The effect of modifications to the serine substituents

AU - Elliott, J. M.

AU - Cascieri, M. A.

AU - Chicchi, G.

AU - Davies, S.

AU - Kelleher, F. J.

AU - Kurtz, M.

AU - Ladduwahetty, T.

AU - Lewis, R. T.

AU - MacLeod, A. M.

AU - Merchant, K. J.

AU - Sadowski, S.

AU - Stevenson, G. I.

PY - 1998/7/21

Y1 - 1998/7/21

N2 - A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.

AB - A series of novel serine derived NK1 antagonists is described. The effect of variations in the N-benzyl, O-benzyl and serine groups are used to define the elements which are necessary for binding.

UR - https://www.scopus.com/pages/publications/0032555069

U2 - 10.1016/S0960-894X(98)00320-5

DO - 10.1016/S0960-894X(98)00320-5

M3 - Article

C2 - 9873445

AN - SCOPUS:0032555069

SN - 0960-894X

VL - 8

SP - 1845

EP - 1850

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 14

ER -

Serine derived NK1 antagonists 1: The effect of modifications to the serine substituents

Abstract

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Serine derived NK₁ antagonists 1: The effect of modifications to the serine substituents