Routes to regioselective deuteriation of heteroaromatic compounds

Wesley R. Browne; Christine M. O'Connor; J. Scott Killeen; Adrian L. Guckian; Micheal Burke; Paraic James; Maurice Burke; Johannes G. Vos

doi:10.1021/ic020226y

Routes to regioselective deuteriation of heteroaromatic compounds

Wesley R. Browne, Christine M. O'Connor, J. Scott Killeen, Adrian L. Guckian, Micheal Burke, Paraic James, Maurice Burke, Johannes G. Vos

Research output: Contribution to journal › Article › peer-review

Abstract

A systematic approach to the deuteriation of polypyridyl type ligands is reported. A range of isotopologues of heteroaromatic compounds containing pyrazyl, pyridyl, 1,2,4-triazole, thienyl, methyl, and phenyl moieties, have been prepared in a cost-effective manner, using a range of methods based on subcritical aqueous media. Selectively and fully deuteriated ligands are characterized by mass spectrometry and ¹H, ²D, and ¹³C NMR spectroscopy. The application of deuteriation to supramolecular chemistry is discussed.

Original language	English
Pages (from-to)	4245-4251
Number of pages	7
Journal	Inorganic Chemistry
Volume	41
Issue number	16
DOIs	https://doi.org/10.1021/ic020226y
Publication status	Published - 12 Aug 2002

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title = "Routes to regioselective deuteriation of heteroaromatic compounds",

abstract = "A systematic approach to the deuteriation of polypyridyl type ligands is reported. A range of isotopologues of heteroaromatic compounds containing pyrazyl, pyridyl, 1,2,4-triazole, thienyl, methyl, and phenyl moieties, have been prepared in a cost-effective manner, using a range of methods based on subcritical aqueous media. Selectively and fully deuteriated ligands are characterized by mass spectrometry and 1H, 2D, and 13C NMR spectroscopy. The application of deuteriation to supramolecular chemistry is discussed.",

author = "Browne, \{Wesley R.\} and O'Connor, \{Christine M.\} and Killeen, \{J. Scott\} and Guckian, \{Adrian L.\} and Micheal Burke and Paraic James and Maurice Burke and Vos, \{Johannes G.\}",

year = "2002",

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doi = "10.1021/ic020226y",

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T1 - Routes to regioselective deuteriation of heteroaromatic compounds

AU - Browne, Wesley R.

AU - O'Connor, Christine M.

AU - Killeen, J. Scott

AU - Guckian, Adrian L.

AU - Burke, Micheal

AU - James, Paraic

AU - Burke, Maurice

AU - Vos, Johannes G.

PY - 2002/8/12

Y1 - 2002/8/12

N2 - A systematic approach to the deuteriation of polypyridyl type ligands is reported. A range of isotopologues of heteroaromatic compounds containing pyrazyl, pyridyl, 1,2,4-triazole, thienyl, methyl, and phenyl moieties, have been prepared in a cost-effective manner, using a range of methods based on subcritical aqueous media. Selectively and fully deuteriated ligands are characterized by mass spectrometry and 1H, 2D, and 13C NMR spectroscopy. The application of deuteriation to supramolecular chemistry is discussed.

AB - A systematic approach to the deuteriation of polypyridyl type ligands is reported. A range of isotopologues of heteroaromatic compounds containing pyrazyl, pyridyl, 1,2,4-triazole, thienyl, methyl, and phenyl moieties, have been prepared in a cost-effective manner, using a range of methods based on subcritical aqueous media. Selectively and fully deuteriated ligands are characterized by mass spectrometry and 1H, 2D, and 13C NMR spectroscopy. The application of deuteriation to supramolecular chemistry is discussed.

UR - https://www.scopus.com/pages/publications/0037068048

U2 - 10.1021/ic020226y

DO - 10.1021/ic020226y

M3 - Article

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AN - SCOPUS:0037068048

SN - 0020-1669

VL - 41

SP - 4245

EP - 4251

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 16

ER -

Routes to regioselective deuteriation of heteroaromatic compounds

Abstract

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