Recent applications of Chemical Imaging to pharmaceutical process monitoring and quality control

A. A. Gowen, C. P. O'Donnell, P. J. Cullen, S. E.J. Bell

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    Chemical Imaging (CI) is an emerging platform technology that integrates conventional imaging and spectroscopy to attain both spatial and spectral information from an object. Vibrational spectroscopic methods, such as Near Infrared (NIR) and Raman spectroscopy, combined with imaging are particularly useful for analysis of biological/pharmaceutical forms. The rapid, non-destructive and non-invasive features of CI mark its potential suitability as a process analytical tool for the pharmaceutical industry, for both process monitoring and quality control in the many stages of drug production. This paper provides an overview of CI principles, instrumentation and analysis. Recent applications of Raman and NIR-CI to pharmaceutical quality and process control are presented; challenges facing CI implementation and likely future developments in the technology are also discussed.

    Original languageEnglish
    Pages (from-to)10-22
    Number of pages13
    JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
    Volume69
    Issue number1
    DOIs
    Publication statusPublished - May 2008

    Keywords

    • Chemical Imaging
    • Drug
    • NIR
    • Non-destructive
    • Pharmaceutical
    • Raman

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