@inproceedings{790b925a1ae04b80adb012b2e6697be2,
title = "Quantifying the concentration of glucose, urea, and lactic acid in mixture by confocal Raman microscopy",
abstract = "Raman spectroscopy has numerous applications in the field of biology. One such application is the simultaneously measurement of the concentration of multiple biochemical components in low volume aqueous mixtures, for example, a single drop of blood serum. Over twenty years ago, it was shown for the first time that it was possible to estimate the concentration of glucose, urea, and lactic acid in mixture by combining Raman Spectroscopy with Partial Least Squares Regression analysis. This was followed by numerous contributions in the literature designed to increase the number of components and reduce the limits of concentration that could be simultaneously measured using Raman spectroscopy, by developing various optical architectures to maximise the signal to noise ratio. The aim of this paper is to demonstrate the potential of a confocal Raman microscopy system for multicomponent analysis for the case of physiologically relevant mixtures of glucose, urea, and lactic acid.",
keywords = "Confocal microscopy, Multiple component analysis, Partial Least Squares Regression, Raman Spectroscopy",
author = "Zhengyuan Tang and Barton, {Sinead J.} and Tomas Ward and John Lowry and Michelle Doran and Byrne, {Hugh J.} and Hennelly, {Bryan M.}",
note = "Publisher Copyright: {\textcopyright} 2018 SPIE.; Biophotonics: Photonic Solutions for Better Health Care VI 2018 ; Conference date: 23-04-2018 Through 26-04-2018",
year = "2018",
doi = "10.1117/12.2307550",
language = "English",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Jurgen Popp and Tuchin, {Valery V.} and Pavone, {Francesco Saverio}",
booktitle = "Biophotonics",
address = "United States",
}