Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones

William Doherty; Jinju James; Paul Evans; Laura Martin; Nikoletta Adler; Derek Nolan; Andrew Knox

doi:10.1039/c4ob01412j

Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones

William Doherty
, Jinju James
, Paul Evans
, Laura Martin
, Nikoletta Adler
, Derek Nolan
, Andrew Knox

School of Chemical and BioPharmaceutical Science

Research output: Contribution to journal › Article › peer-review

Abstract

An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the ε-lysine amino group. Members of this family demonstrated moderate to good efficacy as anti-trypanosomal agents and a fluorescent dansyl (19) derivative was used to investigate subcellular localisation of the compound class.

Original language	English
Pages (from-to)	7561-7571
Number of pages	11
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	38
DOIs	https://doi.org/10.1039/c4ob01412j
Publication status	Published - 14 Oct 2014

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10.1039/c4ob01412j

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title = "Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones",

abstract = "An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the ε-lysine amino group. Members of this family demonstrated moderate to good efficacy as anti-trypanosomal agents and a fluorescent dansyl (19) derivative was used to investigate subcellular localisation of the compound class.",

author = "William Doherty and Jinju James and Paul Evans and Laura Martin and Nikoletta Adler and Derek Nolan and Andrew Knox",

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AU - Doherty, William

AU - James, Jinju

AU - Evans, Paul

AU - Martin, Laura

AU - Adler, Nikoletta

AU - Nolan, Derek

AU - Knox, Andrew

PY - 2014/10/14

Y1 - 2014/10/14

N2 - An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the ε-lysine amino group. Members of this family demonstrated moderate to good efficacy as anti-trypanosomal agents and a fluorescent dansyl (19) derivative was used to investigate subcellular localisation of the compound class.

AB - An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the ε-lysine amino group. Members of this family demonstrated moderate to good efficacy as anti-trypanosomal agents and a fluorescent dansyl (19) derivative was used to investigate subcellular localisation of the compound class.

UR - https://www.scopus.com/pages/publications/84907143604

U2 - 10.1039/c4ob01412j

DO - 10.1039/c4ob01412j

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AN - SCOPUS:84907143604

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VL - 12

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EP - 7571

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 38

ER -

Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones

Abstract

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