Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(μ-terephthalate)(1,10-phen)4]2+n

Andreea Prisecaru; Michael Devereux; Niall Barron; Malachy McCann; John Colleran; Alan Casey; Vickie McKee; Andrew Kellett

doi:10.1039/c2cc31023f

Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu₂(μ-terephthalate)(1,10-phen)₄]²⁺n

Andreea Prisecaru, Michael Devereux, Niall Barron, Malachy McCann, John Colleran, Alan Casey, Vickie McKee, Andrew Kellett

School of Physics, Clinical and Optometric Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The di-copper(II) cation, [Cu₂(μ-terephthalate)(1,10-phen)₄]²⁺, is a powerful, non-sequence-specific, minor-groove oxidizer of duplex DNA which, unlike copper(II) bis-1,10-phenanthroline chloride, operates independently of exogenous reagents. The agent displays excellent in vitro cytoxicity towards cisplatin-resistant ovarian cancer cells, producing intracellular reactive oxygen species upon nano-molar exposure.

Original language	English
Pages (from-to)	6906-6908
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	55
DOIs	https://doi.org/10.1039/c2cc31023f
Publication status	Published - 14 Jun 2012

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title = "Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(μ-terephthalate)(1,10-phen)4]2+n",

abstract = "The di-copper(II) cation, [Cu2(μ-terephthalate)(1,10-phen)4]2+, is a powerful, non-sequence-specific, minor-groove oxidizer of duplex DNA which, unlike copper(II) bis-1,10-phenanthroline chloride, operates independently of exogenous reagents. The agent displays excellent in vitro cytoxicity towards cisplatin-resistant ovarian cancer cells, producing intracellular reactive oxygen species upon nano-molar exposure.",

author = "Andreea Prisecaru and Michael Devereux and Niall Barron and Malachy McCann and John Colleran and Alan Casey and Vickie McKee and Andrew Kellett",

year = "2012",

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doi = "10.1039/c2cc31023f",

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T2 - [Cu2(μ-terephthalate)(1,10-phen)4]2+n

AU - Prisecaru, Andreea

AU - Devereux, Michael

AU - Barron, Niall

AU - McCann, Malachy

AU - Colleran, John

AU - Casey, Alan

AU - McKee, Vickie

AU - Kellett, Andrew

PY - 2012/6/14

Y1 - 2012/6/14

N2 - The di-copper(II) cation, [Cu2(μ-terephthalate)(1,10-phen)4]2+, is a powerful, non-sequence-specific, minor-groove oxidizer of duplex DNA which, unlike copper(II) bis-1,10-phenanthroline chloride, operates independently of exogenous reagents. The agent displays excellent in vitro cytoxicity towards cisplatin-resistant ovarian cancer cells, producing intracellular reactive oxygen species upon nano-molar exposure.

AB - The di-copper(II) cation, [Cu2(μ-terephthalate)(1,10-phen)4]2+, is a powerful, non-sequence-specific, minor-groove oxidizer of duplex DNA which, unlike copper(II) bis-1,10-phenanthroline chloride, operates independently of exogenous reagents. The agent displays excellent in vitro cytoxicity towards cisplatin-resistant ovarian cancer cells, producing intracellular reactive oxygen species upon nano-molar exposure.

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U2 - 10.1039/c2cc31023f

DO - 10.1039/c2cc31023f

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JO - Chemical Communications

JF - Chemical Communications

IS - 55

ER -

Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(μ-terephthalate)(1,10-phen)4]2+n

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Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu₂(μ-terephthalate)(1,10-phen)₄]²⁺n