Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels

D. Daly; A. Al-Sabi; G. K. Kinsella; K. Nolan; J. O. Dolly

doi:10.1039/c4cc05639f

Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels

D. Daly, A. Al-Sabi, G. K. Kinsella, K. Nolan, J. O. Dolly

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Selective inhibitors of voltage-activated K⁺ channels are needed for the treatment of multiple sclerosis. In this work it was discovered that porphyrins bearing 2-4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains.

Original language	English
Pages (from-to)	1066-1069
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	6
DOIs	https://doi.org/10.1039/c4cc05639f
Publication status	Published - 21 Jan 2015
Externally published	Yes

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title = "Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels",

abstract = "Selective inhibitors of voltage-activated K+ channels are needed for the treatment of multiple sclerosis. In this work it was discovered that porphyrins bearing 2-4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains.",

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AU - Al-Sabi, A.

AU - Kinsella, G. K.

AU - Nolan, K.

AU - Dolly, J. O.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

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AB - Selective inhibitors of voltage-activated K+ channels are needed for the treatment of multiple sclerosis. In this work it was discovered that porphyrins bearing 2-4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains.

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SP - 1066

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JO - Chemical Communications

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Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels

Abstract

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