Monitoring and modelling the dynamics of the cellular glycolysis pathway: A review and future perspectives

Nitin Patil; Orla Howe; Paul Cahill; Hugh J. Byrne

doi:10.1016/j.molmet.2022.101635

Monitoring and modelling the dynamics of the cellular glycolysis pathway: A review and future perspectives

Nitin Patil, Orla Howe, Paul Cahill, Hugh J. Byrne

Research output: Contribution to journal › Review article › peer-review

Abstract

Background: The dynamics of the cellular glycolysis pathway underpin cellular function and dysfunction, and therefore ultimately health, disease, diagnostic and therapeutic strategies. Evolving our understanding of this fundamental process and its dynamics remains critical. Scope of review: This paper reviews the medical relevance of glycolytic pathway in depth and explores the current state of the art for monitoring and modelling the dynamics of the process. The future perspectives of label free, vibrational microspectroscopic techniques to overcome the limitations of the current approaches are considered. Major conclusions: Vibrational microspectroscopic techniques can potentially operate in the niche area of limitations of other omics technologies for non-destructive, real-time, in vivo label-free monitoring of glycolysis dynamics at a cellular and subcellular level.

Original language	English
Article number	101635
Journal	Molecular Metabolism
Volume	66
DOIs	https://doi.org/10.1016/j.molmet.2022.101635
Publication status	Published - Dec 2022

Keywords

Cellular metabolism
Chemometrics
Dynamics
Glycolysis
Modelling
Systems biology
Vibrational spectroscopy

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10.1016/j.molmet.2022.101635

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title = "Monitoring and modelling the dynamics of the cellular glycolysis pathway: A review and future perspectives",

abstract = "Background: The dynamics of the cellular glycolysis pathway underpin cellular function and dysfunction, and therefore ultimately health, disease, diagnostic and therapeutic strategies. Evolving our understanding of this fundamental process and its dynamics remains critical. Scope of review: This paper reviews the medical relevance of glycolytic pathway in depth and explores the current state of the art for monitoring and modelling the dynamics of the process. The future perspectives of label free, vibrational microspectroscopic techniques to overcome the limitations of the current approaches are considered. Major conclusions: Vibrational microspectroscopic techniques can potentially operate in the niche area of limitations of other omics technologies for non-destructive, real-time, in vivo label-free monitoring of glycolysis dynamics at a cellular and subcellular level.",

keywords = "Cellular metabolism, Chemometrics, Dynamics, Glycolysis, Modelling, Systems biology, Vibrational spectroscopy",

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doi = "10.1016/j.molmet.2022.101635",

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T1 - Monitoring and modelling the dynamics of the cellular glycolysis pathway

T2 - A review and future perspectives

AU - Patil, Nitin

AU - Howe, Orla

AU - Cahill, Paul

AU - Byrne, Hugh J.

PY - 2022/12

Y1 - 2022/12

N2 - Background: The dynamics of the cellular glycolysis pathway underpin cellular function and dysfunction, and therefore ultimately health, disease, diagnostic and therapeutic strategies. Evolving our understanding of this fundamental process and its dynamics remains critical. Scope of review: This paper reviews the medical relevance of glycolytic pathway in depth and explores the current state of the art for monitoring and modelling the dynamics of the process. The future perspectives of label free, vibrational microspectroscopic techniques to overcome the limitations of the current approaches are considered. Major conclusions: Vibrational microspectroscopic techniques can potentially operate in the niche area of limitations of other omics technologies for non-destructive, real-time, in vivo label-free monitoring of glycolysis dynamics at a cellular and subcellular level.

AB - Background: The dynamics of the cellular glycolysis pathway underpin cellular function and dysfunction, and therefore ultimately health, disease, diagnostic and therapeutic strategies. Evolving our understanding of this fundamental process and its dynamics remains critical. Scope of review: This paper reviews the medical relevance of glycolytic pathway in depth and explores the current state of the art for monitoring and modelling the dynamics of the process. The future perspectives of label free, vibrational microspectroscopic techniques to overcome the limitations of the current approaches are considered. Major conclusions: Vibrational microspectroscopic techniques can potentially operate in the niche area of limitations of other omics technologies for non-destructive, real-time, in vivo label-free monitoring of glycolysis dynamics at a cellular and subcellular level.

KW - Cellular metabolism

KW - Chemometrics

KW - Dynamics

KW - Glycolysis

KW - Modelling

KW - Systems biology

KW - Vibrational spectroscopy

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Monitoring and modelling the dynamics of the cellular glycolysis pathway: A review and future perspectives

Abstract

Keywords

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