TY - JOUR
T1 - Molecularly imprinted polymers based biomimetic sensors for mosapride citrate detection in biological fluids
AU - El Nashar, Rasha Mohamed
AU - Abdel Ghani, Nour T.
AU - El Gohary, Nesrine A.
AU - Barhoum, A.
AU - Madbouly, Adel
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Computational modeling was applied to study the intermolecular interactions in the pre-polymerization mixture and find a suitable functional monomer to use in the design of a new molecularly imprinted polymer (MIP) for mosapride citrate which is considerably a large molecule (as the citrate ion is also included in calculations as it has centers that can take part in interaction with monomer via hydrogen bonding). Based on these calculations, methacyrlic acid (MAA) was selected as a suitable functional monomer. Mosapride citrate selective MIP and a non-imprinted polymer (NIP) were synthesized and characterized using FTIR, TGA and SEM and then incorporated in carbon paste electrodes (CPEs). The designed modified sensor revealed linear responses in the ranges of 1 × 10− 4–8 × 10− 7 and 8 × 10− 7–8 × 10− 8 mol L− 1 with a limit of detection (LOD) of 2.6 × 10− 8 mol L− 1. The results of the sensor exhibited high selectivity over interfering species and could be applied for the determination of mosapride citrate in pure solutions, pharmaceutical preparations, urine and human serum samples.
AB - Computational modeling was applied to study the intermolecular interactions in the pre-polymerization mixture and find a suitable functional monomer to use in the design of a new molecularly imprinted polymer (MIP) for mosapride citrate which is considerably a large molecule (as the citrate ion is also included in calculations as it has centers that can take part in interaction with monomer via hydrogen bonding). Based on these calculations, methacyrlic acid (MAA) was selected as a suitable functional monomer. Mosapride citrate selective MIP and a non-imprinted polymer (NIP) were synthesized and characterized using FTIR, TGA and SEM and then incorporated in carbon paste electrodes (CPEs). The designed modified sensor revealed linear responses in the ranges of 1 × 10− 4–8 × 10− 7 and 8 × 10− 7–8 × 10− 8 mol L− 1 with a limit of detection (LOD) of 2.6 × 10− 8 mol L− 1. The results of the sensor exhibited high selectivity over interfering species and could be applied for the determination of mosapride citrate in pure solutions, pharmaceutical preparations, urine and human serum samples.
KW - Computational studies
KW - Molecularly imprinted polymer
KW - Mosapride citrate
KW - Pharmaceutical analysis
KW - Sensor
KW - Voltammetry
UR - https://www.scopus.com/pages/publications/85015043295
U2 - 10.1016/j.msec.2017.03.087
DO - 10.1016/j.msec.2017.03.087
M3 - Article
C2 - 28482490
AN - SCOPUS:85015043295
SN - 0928-4931
VL - 76
SP - 123
EP - 129
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
ER -