Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes

Basista Rabina Sharma; Swarna Jaiswal; P. V. Ravindra

doi:10.1016/j.biopha.2022.113148

Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes

Basista Rabina Sharma, Swarna Jaiswal, P. V. Ravindra

School of Food Science and Environmental Health

Research output: Contribution to journal › Review article › peer-review

Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, disease protection, and associated with metabolic activities, and play a vital role in the production of functional metabolites from dietary substances. Dysbiosis of GM has been linked to the onset of T2DM and can be altered to attain eubiosis by intervention with various nutritional bioactive compounds such as polyphenols, prebiotics, and probiotics. This review presents an overview of the evidence and underlying mechanisms by which bioactive compounds modulate the GM for the prevention and management of T2DM.

Original language	English
Article number	113148
Journal	Biomedicine and Pharmacotherapy
Volume	152
DOIs	https://doi.org/10.1016/j.biopha.2022.113148
Publication status	Published - Aug 2022

Keywords

Dysbiosis
Eubiosis
Gut microbiota
Type 2 diabetes

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title = "Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes",

abstract = "Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, disease protection, and associated with metabolic activities, and play a vital role in the production of functional metabolites from dietary substances. Dysbiosis of GM has been linked to the onset of T2DM and can be altered to attain eubiosis by intervention with various nutritional bioactive compounds such as polyphenols, prebiotics, and probiotics. This review presents an overview of the evidence and underlying mechanisms by which bioactive compounds modulate the GM for the prevention and management of T2DM.",

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AU - Sharma, Basista Rabina

AU - Jaiswal, Swarna

AU - Ravindra, P. V.

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N2 - Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, disease protection, and associated with metabolic activities, and play a vital role in the production of functional metabolites from dietary substances. Dysbiosis of GM has been linked to the onset of T2DM and can be altered to attain eubiosis by intervention with various nutritional bioactive compounds such as polyphenols, prebiotics, and probiotics. This review presents an overview of the evidence and underlying mechanisms by which bioactive compounds modulate the GM for the prevention and management of T2DM.

AB - Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, disease protection, and associated with metabolic activities, and play a vital role in the production of functional metabolites from dietary substances. Dysbiosis of GM has been linked to the onset of T2DM and can be altered to attain eubiosis by intervention with various nutritional bioactive compounds such as polyphenols, prebiotics, and probiotics. This review presents an overview of the evidence and underlying mechanisms by which bioactive compounds modulate the GM for the prevention and management of T2DM.

KW - Dysbiosis

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Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes

Abstract

Keywords

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