Methods to assess the direct interaction of C. jejuni with mucins

Marguerite Clyne, Gina Duggan, Julie Naughton, Billy Bourke

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Studies of the interaction of bacteria with mucus-secreting cells can be complemented at a more mechanistic level by exploring the interaction of bacteria with purified mucins. Here we describe a far Western blotting approach to show how C. jejuni proteins separated by SDS PAGE and transferred to a membrane or slot blotted directly onto a membrane can be probed using biotinylated mucin. In addition we describe the use of novel mucin microarrays to assess bacterial interactions with mucins in a high-throughput manner.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages107-115
Number of pages9
DOIs
Publication statusPublished - 2017
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1512
ISSN (Print)1064-3745

Keywords

  • Campylobacter jejuni
  • Mucin array
  • Mucus
  • PVDF
  • SDS PAGE
  • Slot blot

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