Abstract
We consider the physical nature of the self-diffusion of water molecules in tissue and explore how (Nuclear) Magnetic Resonance (MR) imaging may be used as a means of measuring the rate of diffusion in vivo. A discussion is presented on how these techniques may be implemented as a non-invasive means of assessing the response of tumours to novel therapeutics including some of the basic advantages and disadvan- tages when compared to other methods. The physical basis and mathematical models for diffusion are considered together with models for the distribution of the diffusion co- efficient including a Lévy distributed model. Using a Lévy distributed diffusion model, we develop a novel algorithm for the purpose of improving the signal-to-noise ratio of MR images.
| Original language | English |
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| DOIs | |
| Publication status | Published - 2011 |
| Externally published | Yes |
| Event | 10th International Conference on Environment and Electrical Engineering EEEIC 2011 - Rome, Italy Duration: 1 Jan 2011 → … |
Conference
| Conference | 10th International Conference on Environment and Electrical Engineering EEEIC 2011 |
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| Country/Territory | Italy |
| City | Rome |
| Period | 1/01/11 → … |
Keywords
- self-diffusion
- water molecules
- tissue
- Nuclear Magnetic Resonance
- MR imaging
- diffusion in vivo
- non-invasive
- tumours
- therapeutics
- signal-to-noise ratio
- Lévy distributed model