TY - JOUR
T1 - Inverse relationship between physical activity, adiposity, and arterial stiffness in healthy middle-aged subjects
AU - Ananey, Oscar Mac
AU - McLoughlin, Brendan
AU - Leonard, Ann
AU - Maher, Lewena
AU - Gaffney, Peter
AU - Boran, Gerard
AU - Maher, Vincent
N1 - Publisher Copyright:
© 2015 Human Kinetics, Inc.
PY - 2015/12
Y1 - 2015/12
N2 - Background: Several obesity related factors are reported to exacerbate premature arterial stiffening, including inactivity and metabolic disarray. The aim of the current study was to investigate the relationship between physical activity, arterial stiffness and adiposity using objective methods. To further explore the role of adiposity in this complex process, obesity associated anthropometric and humoral biomarkers were measured. Methods: Seventy-nine healthy, lifelong nonsmoking subjects were recruited. Habitual physical activity was measured using accelerometry. Arterial stiffness [augmentation index (AIx) and pulse wave velocity (PWV)] was measured using tonometry. Body composition was estimated using bioimpedence. Adipose associated biomarkers, leptin and adiponectin, were also measured. Results: Sedentary time was significantly associated with AIx (r = 0.38, P <.001), PWV (r = 0.33, P <.01), body fat composition (r = 0.40, P <.001) and age (r = 0.30, P <.01). Moderate-to-vigorous physical activity (MVPA) was inversely correlated with AIx (r = -0.28, P <.05), body fat composition (r = -0.30, P <.01), postprandial insulin (r = -0.35, P <.01), and leptin/adiponectin ratio (r = -0.28, P <.05). MVPA, body fat composition, and postprandial insulin remained independent predictors of AIx but not PWV. Conclusion: The more time healthy individuals spend being sedentary, the greater their body fat and arterial stiffness. Conversely higher activity levels are associated with reduced body fat and less arterial stiffness.
AB - Background: Several obesity related factors are reported to exacerbate premature arterial stiffening, including inactivity and metabolic disarray. The aim of the current study was to investigate the relationship between physical activity, arterial stiffness and adiposity using objective methods. To further explore the role of adiposity in this complex process, obesity associated anthropometric and humoral biomarkers were measured. Methods: Seventy-nine healthy, lifelong nonsmoking subjects were recruited. Habitual physical activity was measured using accelerometry. Arterial stiffness [augmentation index (AIx) and pulse wave velocity (PWV)] was measured using tonometry. Body composition was estimated using bioimpedence. Adipose associated biomarkers, leptin and adiponectin, were also measured. Results: Sedentary time was significantly associated with AIx (r = 0.38, P <.001), PWV (r = 0.33, P <.01), body fat composition (r = 0.40, P <.001) and age (r = 0.30, P <.01). Moderate-to-vigorous physical activity (MVPA) was inversely correlated with AIx (r = -0.28, P <.05), body fat composition (r = -0.30, P <.01), postprandial insulin (r = -0.35, P <.01), and leptin/adiponectin ratio (r = -0.28, P <.05). MVPA, body fat composition, and postprandial insulin remained independent predictors of AIx but not PWV. Conclusion: The more time healthy individuals spend being sedentary, the greater their body fat and arterial stiffness. Conversely higher activity levels are associated with reduced body fat and less arterial stiffness.
KW - Augmentation
KW - Obesity
KW - Pulse wave velocity
UR - http://www.scopus.com/inward/record.url?scp=84961741460&partnerID=8YFLogxK
U2 - 10.1123/jpah.2014-0395
DO - 10.1123/jpah.2014-0395
M3 - Article
SN - 1543-3080
VL - 12
SP - 1576
EP - 1581
JO - Journal of Physical Activity and Health
JF - Journal of Physical Activity and Health
IS - 12
ER -