In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy

Susan Callaghan; Mikhail A. Filatov; Huguette Savoie; Ross W. Boyle; Mathias O. Senge

doi:10.1039/C8PP00402A

In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy

Susan Callaghan, Mikhail A. Filatov, Huguette Savoie, Ross W. Boyle, Mathias O. Senge

Research output: Contribution to journal › Article › peer-review

Abstract

The facile synthesis and in vitro activity of a library of heavy atom-free BODIPY-anthracene, -pyrene dyads (BAD-13-BPyrD-19) and a control (BODIPY 20) are reported. We demonstrate that singlet oxygen produced from dyad triplet states formed from charge-separated states is sufficient to induce cytotoxicity in human breast cancer cells (MDA-MB-468) at micromolar concentrations. The compounds in this series are promising candidates for photodynamic therapy, especially BAD-17 which displays significant photocytotoxicity (15% cell viability) at a concentration of 5 × 10⁻⁷ M, with minimal toxicity (89% cell viability) in the absence of light.

Original language	English
Pages (from-to)	495-504
Number of pages	10
Journal	Photochemical and Photobiological Sciences
Volume	18
Issue number	2
DOIs	https://doi.org/10.1039/C8PP00402A
Publication status	Published - 2019
Externally published	Yes

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abstract = "The facile synthesis and in vitro activity of a library of heavy atom-free BODIPY-anthracene, -pyrene dyads (BAD-13-BPyrD-19) and a control (BODIPY 20) are reported. We demonstrate that singlet oxygen produced from dyad triplet states formed from charge-separated states is sufficient to induce cytotoxicity in human breast cancer cells (MDA-MB-468) at micromolar concentrations. The compounds in this series are promising candidates for photodynamic therapy, especially BAD-17 which displays significant photocytotoxicity (15% cell viability) at a concentration of 5 × 10−7 M, with minimal toxicity (89% cell viability) in the absence of light.",

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AU - Filatov, Mikhail A.

AU - Savoie, Huguette

AU - Boyle, Ross W.

AU - Senge, Mathias O.

N1 - Publisher Copyright: © The Royal Society of Chemistry and Owner Societies.

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AB - The facile synthesis and in vitro activity of a library of heavy atom-free BODIPY-anthracene, -pyrene dyads (BAD-13-BPyrD-19) and a control (BODIPY 20) are reported. We demonstrate that singlet oxygen produced from dyad triplet states formed from charge-separated states is sufficient to induce cytotoxicity in human breast cancer cells (MDA-MB-468) at micromolar concentrations. The compounds in this series are promising candidates for photodynamic therapy, especially BAD-17 which displays significant photocytotoxicity (15% cell viability) at a concentration of 5 × 10−7 M, with minimal toxicity (89% cell viability) in the absence of light.

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In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy

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