Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase

Muhammad Akram; Melanie Patt; Teresa Kaserer; Veronika Temml; Watcharee Waratchareeyakul; Denise V. Kratschmar; Joerg Haupenthal; Rolf W. Hartmann; Alex Odermatt; Daniela Schuster

doi:10.1016/j.jsbmb.2019.04.007

Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase

Muhammad Akram
, Melanie Patt
, Teresa Kaserer
, Veronika Temml
, Watcharee Waratchareeyakul
, Denise V. Kratschmar
, Joerg Haupenthal
, Rolf W. Hartmann
, Alex Odermatt
, Daniela Schuster

Research output: Contribution to journal › Article › peer-review

Original language	English
Article number	105358
Journal	Journal of Steroid Biochemistry and Molecular Biology
Volume	192
DOIs	https://doi.org/10.1016/j.jsbmb.2019.04.007
Publication status	Published - Sep 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Aldosterone synthase
Cortisol synthase
Endocrine disruption
Environmental chemical
Fungicide
Pharmacophore modeling
Steroidogenesis
Virtual screening

Access to Document

10.1016/j.jsbmb.2019.04.007

Cite this

Akram, M., Patt, M., Kaserer, T., Temml, V., Waratchareeyakul, W., Kratschmar, D. V., Haupenthal, J., Hartmann, R. W., Odermatt, A., & Schuster, D. (2019). Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase. Journal of Steroid Biochemistry and Molecular Biology, 192, Article 105358. https://doi.org/10.1016/j.jsbmb.2019.04.007

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title = "Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase",

keywords = "Aldosterone synthase, Cortisol synthase, Endocrine disruption, Environmental chemical, Fungicide, Pharmacophore modeling, Steroidogenesis, Virtual screening",

author = "Muhammad Akram and Melanie Patt and Teresa Kaserer and Veronika Temml and Watcharee Waratchareeyakul and Kratschmar, \{Denise V.\} and Joerg Haupenthal and Hartmann, \{Rolf W.\} and Alex Odermatt and Daniela Schuster",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = sep,

doi = "10.1016/j.jsbmb.2019.04.007",

language = "English",

volume = "192",

journal = "Journal of Steroid Biochemistry and Molecular Biology",

issn = "0960-0760",

publisher = "Elsevier Ltd.",

}

Akram, M, Patt, M, Kaserer, T, Temml, V, Waratchareeyakul, W, Kratschmar, DV, Haupenthal, J, Hartmann, RW, Odermatt, A & Schuster, D 2019, 'Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase', Journal of Steroid Biochemistry and Molecular Biology, vol. 192, 105358. https://doi.org/10.1016/j.jsbmb.2019.04.007

TY - JOUR

T1 - Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase

AU - Akram, Muhammad

AU - Patt, Melanie

AU - Kaserer, Teresa

AU - Temml, Veronika

AU - Waratchareeyakul, Watcharee

AU - Kratschmar, Denise V.

AU - Haupenthal, Joerg

AU - Hartmann, Rolf W.

AU - Odermatt, Alex

AU - Schuster, Daniela

PY - 2019/9

Y1 - 2019/9

KW - Aldosterone synthase

KW - Cortisol synthase

KW - Endocrine disruption

KW - Environmental chemical

KW - Fungicide

KW - Pharmacophore modeling

KW - Steroidogenesis

KW - Virtual screening

UR - https://www.scopus.com/pages/publications/85067333225

U2 - 10.1016/j.jsbmb.2019.04.007

DO - 10.1016/j.jsbmb.2019.04.007

M3 - Article

SN - 0960-0760

VL - 192

JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

M1 - 105358

ER -