Identification of precancer oral lesions using minimally invasive sampling techniques and Raman microspectroscopy

Isha Behl; Genecy Calado; Alison Malkin; Stephen Flint; Sheila Galvin; Claire M. Healy; Hugh J. Byrne; Fiona M. Lyng

doi:10.1117/12.2654997

Identification of precancer oral lesions using minimally invasive sampling techniques and Raman microspectroscopy

Isha Behl
, Genecy Calado
, Alison Malkin
, Stephen Flint
, Sheila Galvin
, Claire M. Healy
, Hugh J. Byrne
, Fiona M. Lyng

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The gold standard diagnosis of oral pre-cancer/cancer is an invasive biopsy followed by a histological examination, which may present psychological trauma and risk of infection to patients. Moreover, multiple biopsies are often required to monitor precancer lesions' progression. With the aim of reducing the need for multiple biopsies, this study was undertaken to identify pre-cancerous lesions using minimally invasive brush biopsy and saliva samples, analysed by Raman spectroscopy.

Original language	English
Title of host publication	Optical Biopsy XXI
Subtitle of host publication	Toward Real-Time Spectroscopic Imaging and Diagnosis
Editors	Robert R. Alfano, Angela B. Seddon
Publisher	SPIE
ISBN (Electronic)	9781510658516
DOIs	https://doi.org/10.1117/12.2654997
Publication status	Published - 2023
Event	Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis 2023 - San Francisco, United States Duration: 31 Jan 2023 → 1 Feb 2023

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	12373
ISSN (Print)	1605-7422

Conference

Conference	Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis 2023
Country/Territory	United States
City	San Francisco
Period	31/01/23 → 1/02/23

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Oral precancer
Raman spectroscopy
brush biopsy
partial least square discriminant analysis
saliva

Access to Document

10.1117/12.2654997

https://arrow.tudublin.ie/radcon/17Licence: CC BY-NC-SA

Cite this

Behl, I., Calado, G., Malkin, A., Flint, S., Galvin, S., Healy, C. M., Byrne, H. J., & Lyng, F. M. (2023). Identification of precancer oral lesions using minimally invasive sampling techniques and Raman microspectroscopy. In R. R. Alfano, & A. B. Seddon (Eds.), Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis Article 1237305 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12373). SPIE. https://doi.org/10.1117/12.2654997

@inproceedings{04bf17ef0e424513a14124e35e5db929,

title = "Identification of precancer oral lesions using minimally invasive sampling techniques and Raman microspectroscopy",

abstract = "The gold standard diagnosis of oral pre-cancer/cancer is an invasive biopsy followed by a histological examination, which may present psychological trauma and risk of infection to patients. Moreover, multiple biopsies are often required to monitor precancer lesions' progression. With the aim of reducing the need for multiple biopsies, this study was undertaken to identify pre-cancerous lesions using minimally invasive brush biopsy and saliva samples, analysed by Raman spectroscopy.",

keywords = "Oral precancer, Raman spectroscopy, brush biopsy, partial least square discriminant analysis, saliva",

author = "Isha Behl and Genecy Calado and Alison Malkin and Stephen Flint and Sheila Galvin and Healy, \{Claire M.\} and Byrne, \{Hugh J.\} and Lyng, \{Fiona M.\}",

note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis 2023 ; Conference date: 31-01-2023 Through 01-02-2023",

year = "2023",

doi = "10.1117/12.2654997",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Alfano, \{Robert R.\} and Seddon, \{Angela B.\}",

booktitle = "Optical Biopsy XXI",

address = "United States",

}

Behl, I, Calado, G, Malkin, A, Flint, S, Galvin, S, Healy, CM, Byrne, HJ & Lyng, FM 2023, Identification of precancer oral lesions using minimally invasive sampling techniques and Raman microspectroscopy. in RR Alfano & AB Seddon (eds), Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis., 1237305, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12373, SPIE, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis 2023, San Francisco, United States, 31/01/23. https://doi.org/10.1117/12.2654997

Identification of precancer oral lesions using minimally invasive sampling techniques and Raman microspectroscopy. / Behl, Isha; Calado, Genecy; Malkin, Alison et al.
Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis. ed. / Robert R. Alfano; Angela B. Seddon. SPIE, 2023. 1237305 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12373).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Identification of precancer oral lesions using minimally invasive sampling techniques and Raman microspectroscopy

AU - Behl, Isha

AU - Calado, Genecy

AU - Malkin, Alison

AU - Flint, Stephen

AU - Galvin, Sheila

AU - Healy, Claire M.

AU - Byrne, Hugh J.

AU - Lyng, Fiona M.

PY - 2023

Y1 - 2023

N2 - The gold standard diagnosis of oral pre-cancer/cancer is an invasive biopsy followed by a histological examination, which may present psychological trauma and risk of infection to patients. Moreover, multiple biopsies are often required to monitor precancer lesions' progression. With the aim of reducing the need for multiple biopsies, this study was undertaken to identify pre-cancerous lesions using minimally invasive brush biopsy and saliva samples, analysed by Raman spectroscopy.

AB - The gold standard diagnosis of oral pre-cancer/cancer is an invasive biopsy followed by a histological examination, which may present psychological trauma and risk of infection to patients. Moreover, multiple biopsies are often required to monitor precancer lesions' progression. With the aim of reducing the need for multiple biopsies, this study was undertaken to identify pre-cancerous lesions using minimally invasive brush biopsy and saliva samples, analysed by Raman spectroscopy.

KW - Oral precancer

KW - Raman spectroscopy

KW - brush biopsy

KW - partial least square discriminant analysis

KW - saliva

UR - https://www.scopus.com/pages/publications/85152766832

U2 - 10.1117/12.2654997

DO - 10.1117/12.2654997

M3 - Conference contribution

AN - SCOPUS:85152766832

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Optical Biopsy XXI

A2 - Alfano, Robert R.

A2 - Seddon, Angela B.

PB - SPIE

T2 - Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis 2023

Y2 - 31 January 2023 through 1 February 2023

ER -

Behl I, Calado G, Malkin A, Flint S, Galvin S, Healy CM et al. Identification of precancer oral lesions using minimally invasive sampling techniques and Raman microspectroscopy. In Alfano RR, Seddon AB, editors, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis. SPIE. 2023. 1237305. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2654997

Identification of precancer oral lesions using minimally invasive sampling techniques and Raman microspectroscopy

Abstract

Publication series

Conference

UN SDGs

Keywords

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