Identification of precancer oral lesions using minimally invasive sampling techniques and Raman microspectroscopy

Isha Behl, Genecy Calado, Alison Malkin, Stephen Flint, Sheila Galvin, Claire M. Healy, Hugh J. Byrne, Fiona M. Lyng

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The gold standard diagnosis of oral pre-cancer/cancer is an invasive biopsy followed by a histological examination, which may present psychological trauma and risk of infection to patients. Moreover, multiple biopsies are often required to monitor precancer lesions' progression. With the aim of reducing the need for multiple biopsies, this study was undertaken to identify pre-cancerous lesions using minimally invasive brush biopsy and saliva samples, analysed by Raman spectroscopy.

Original languageEnglish
Title of host publicationOptical Biopsy XXI
Subtitle of host publicationToward Real-Time Spectroscopic Imaging and Diagnosis
EditorsRobert R. Alfano, Angela B. Seddon
PublisherSPIE
ISBN (Electronic)9781510658516
DOIs
Publication statusPublished - 2023
EventOptical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis 2023 - San Francisco, United States
Duration: 31 Jan 20231 Feb 2023

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12373
ISSN (Print)1605-7422

Conference

ConferenceOptical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis 2023
Country/TerritoryUnited States
CitySan Francisco
Period31/01/231/02/23

Keywords

  • Oral precancer
  • Raman spectroscopy
  • brush biopsy
  • partial least square discriminant analysis
  • saliva

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