HLAfreq: Download and combine HLA allele frequency data

Human leukocyte antigen (HLA) genes encode cell-surface proteins which play an important role in immunity. Since different HLA alleles enable different immune responses, the population frequency of HLA alleles is often considered when designing vaccines (Gulukota & DeLisi, 1996). Specific HLA alleles have been linked to autoimmune disease (Simmonds & Gough, 2007) and associated with adverse drug reactions (Fan et al., 2017). Further, the success of solid organ and stem cell transplants is related to HLA matching between donor and recipient (Fürst et al., 2019; Morishima et al., 2002). We present HLAfreq, a Python package which can be used to download, combine and analyse multiple HLA allele frequency datasets.