Enhancement of the antibacterial properties of silver nanoparticles using β-cyclodextrin as a capping agent

Swarna Jaiswal; Brendan Duffy; Amit Kumar Jaiswal; Niall Stobie; Patrick McHale

doi:10.1016/j.ijantimicag.2010.05.006

Enhancement of the antibacterial properties of silver nanoparticles using β-cyclodextrin as a capping agent

Swarna Jaiswal, Brendan Duffy, Amit Kumar Jaiswal, Niall Stobie, Patrick McHale

Research output: Contribution to journal › Article › peer-review

Abstract

Silver nanoparticles (AgNPs) were synthesised by reducing silver salts using NaBH₄ followed by capping with varying concentrations of β-cyclodextrin (β-CD) and were physically characterised. Antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus was determined by a microtitre well method. The AgNPs were spherical under transmission electron microscopy, whilst dynamic light scattering showed average diameters of capped particles to be smaller (4-7nm) than their uncapped equivalents (17nm). Capped particles demonstrated superior photostability when exposed to intense ultraviolet radiation for 4h as well as significantly (P<0.05) higher (up to 3.5-fold) antibacterial activity. The influence of β-CD concentration was seen to delay bacterial growth, indicating that a Trojan horse mechanism may be occurring owing to bacterial carbohydrate affinity, thereby enhancing silver ion absorption.

Original language	English
Pages (from-to)	280-283
Number of pages	4
Journal	International Journal of Antimicrobial Agents
Volume	36
Issue number	3
DOIs	https://doi.org/10.1016/j.ijantimicag.2010.05.006
Publication status	Published - Sep 2010

Keywords

Antibacterial activity
Silver nanoparticles
β-Cyclodextrin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijantimicag.2010.05.006

https://arrow.tudublin.ie/cenresart/2Licence: CC BY-NC-SA

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title = "Enhancement of the antibacterial properties of silver nanoparticles using β-cyclodextrin as a capping agent",

abstract = "Silver nanoparticles (AgNPs) were synthesised by reducing silver salts using NaBH4 followed by capping with varying concentrations of β-cyclodextrin (β-CD) and were physically characterised. Antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus was determined by a microtitre well method. The AgNPs were spherical under transmission electron microscopy, whilst dynamic light scattering showed average diameters of capped particles to be smaller (4-7nm) than their uncapped equivalents (17nm). Capped particles demonstrated superior photostability when exposed to intense ultraviolet radiation for 4h as well as significantly (P<0.05) higher (up to 3.5-fold) antibacterial activity. The influence of β-CD concentration was seen to delay bacterial growth, indicating that a Trojan horse mechanism may be occurring owing to bacterial carbohydrate affinity, thereby enhancing silver ion absorption.",

keywords = "Antibacterial activity, Silver nanoparticles, β-Cyclodextrin",

author = "Swarna Jaiswal and Brendan Duffy and Jaiswal, \{Amit Kumar\} and Niall Stobie and Patrick McHale",

note = "Funding Information: Funding : The authors wish to acknowledge the Dublin Institute of Technology (Dublin, Ireland) for funding under the ABBEST scholarship programme (SJ) and Enterprise Ireland under the ARE Programme (BD and NS). ",

year = "2010",

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doi = "10.1016/j.ijantimicag.2010.05.006",

language = "English",

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pages = "280--283",

journal = "International Journal of Antimicrobial Agents",

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AU - Jaiswal, Swarna

AU - Duffy, Brendan

AU - Jaiswal, Amit Kumar

AU - Stobie, Niall

AU - McHale, Patrick

N1 - Funding Information: Funding : The authors wish to acknowledge the Dublin Institute of Technology (Dublin, Ireland) for funding under the ABBEST scholarship programme (SJ) and Enterprise Ireland under the ARE Programme (BD and NS).

PY - 2010/9

Y1 - 2010/9

N2 - Silver nanoparticles (AgNPs) were synthesised by reducing silver salts using NaBH4 followed by capping with varying concentrations of β-cyclodextrin (β-CD) and were physically characterised. Antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus was determined by a microtitre well method. The AgNPs were spherical under transmission electron microscopy, whilst dynamic light scattering showed average diameters of capped particles to be smaller (4-7nm) than their uncapped equivalents (17nm). Capped particles demonstrated superior photostability when exposed to intense ultraviolet radiation for 4h as well as significantly (P<0.05) higher (up to 3.5-fold) antibacterial activity. The influence of β-CD concentration was seen to delay bacterial growth, indicating that a Trojan horse mechanism may be occurring owing to bacterial carbohydrate affinity, thereby enhancing silver ion absorption.

AB - Silver nanoparticles (AgNPs) were synthesised by reducing silver salts using NaBH4 followed by capping with varying concentrations of β-cyclodextrin (β-CD) and were physically characterised. Antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus was determined by a microtitre well method. The AgNPs were spherical under transmission electron microscopy, whilst dynamic light scattering showed average diameters of capped particles to be smaller (4-7nm) than their uncapped equivalents (17nm). Capped particles demonstrated superior photostability when exposed to intense ultraviolet radiation for 4h as well as significantly (P<0.05) higher (up to 3.5-fold) antibacterial activity. The influence of β-CD concentration was seen to delay bacterial growth, indicating that a Trojan horse mechanism may be occurring owing to bacterial carbohydrate affinity, thereby enhancing silver ion absorption.

KW - Antibacterial activity

KW - Silver nanoparticles

KW - β-Cyclodextrin

UR - https://www.scopus.com/pages/publications/77954960024

U2 - 10.1016/j.ijantimicag.2010.05.006

DO - 10.1016/j.ijantimicag.2010.05.006

M3 - Article

C2 - 20580208

AN - SCOPUS:77954960024

SN - 0924-8579

VL - 36

SP - 280

EP - 283

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 3

ER -

Enhancement of the antibacterial properties of silver nanoparticles using β-cyclodextrin as a capping agent

Abstract

Keywords

UN SDGs

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