Effect of motion on the ADC quantification accuracy of whole-body DWIBS

Alan J. Stone; Jacinta E. Browne; Brian Lennon; James F. Meaney; Andrew J. Fagan

doi:10.1007/s10334-012-0311-1

Effect of motion on the ADC quantification accuracy of whole-body DWIBS

Alan J. Stone
, Jacinta E. Browne
, Brian Lennon
, James F. Meaney
, Andrew J. Fagan

School of Physics, Clinical and Optometric Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Background and methods Diffusion-weighted wholebody imaging with background body signal subtraction was introduced as a qualitative approach to detecting metastases in the body. A liver-mimicking phantom with embedded tumours that could be moved to replicate respiratory motion was developed to assess its ability to accurately quantify ADC values. Results Mean tumour ADC values were unaltered by the motion; however, a significant (p < 0.05) increase in the spread of ADC values was measured, even for relatively large tumours. Conclusions These findings may be of significance in cancer therapy monitoring where subtle changes in ADC histograms may reveal changes in tumour heterogeneity.

Original language	English
Pages (from-to)	263-266
Number of pages	4
Journal	Magnetic Resonance Materials in Physics, Biology and Medicine
Volume	25
Issue number	4
DOIs	https://doi.org/10.1007/s10334-012-0311-1
Publication status	Published - Aug 2012

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apparent diffusion coefficient
DWIBS
Diffusion-weighted imaging
Liver Free breathing
Motion phantom

Access to Document

10.1007/s10334-012-0311-1

https://arrow.tudublin.ie/scschphyart/55Licence: CC BY-NC-SA

Cite this

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title = "Effect of motion on the ADC quantification accuracy of whole-body DWIBS",

abstract = "Background and methods Diffusion-weighted wholebody imaging with background body signal subtraction was introduced as a qualitative approach to detecting metastases in the body. A liver-mimicking phantom with embedded tumours that could be moved to replicate respiratory motion was developed to assess its ability to accurately quantify ADC values. Results Mean tumour ADC values were unaltered by the motion; however, a significant (p < 0.05) increase in the spread of ADC values was measured, even for relatively large tumours. Conclusions These findings may be of significance in cancer therapy monitoring where subtle changes in ADC histograms may reveal changes in tumour heterogeneity.",

keywords = "Apparent diffusion coefficient, DWIBS, Diffusion-weighted imaging, Liver Free breathing, Motion phantom",

author = "Stone, \{Alan J.\} and Browne, \{Jacinta E.\} and Brian Lennon and Meaney, \{James F.\} and Fagan, \{Andrew J.\}",

year = "2012",

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doi = "10.1007/s10334-012-0311-1",

language = "English",

volume = "25",

pages = "263--266",

journal = "Magnetic Resonance Materials in Physics, Biology and Medicine",

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T1 - Effect of motion on the ADC quantification accuracy of whole-body DWIBS

AU - Stone, Alan J.

AU - Browne, Jacinta E.

AU - Lennon, Brian

AU - Meaney, James F.

AU - Fagan, Andrew J.

PY - 2012/8

Y1 - 2012/8

N2 - Background and methods Diffusion-weighted wholebody imaging with background body signal subtraction was introduced as a qualitative approach to detecting metastases in the body. A liver-mimicking phantom with embedded tumours that could be moved to replicate respiratory motion was developed to assess its ability to accurately quantify ADC values. Results Mean tumour ADC values were unaltered by the motion; however, a significant (p < 0.05) increase in the spread of ADC values was measured, even for relatively large tumours. Conclusions These findings may be of significance in cancer therapy monitoring where subtle changes in ADC histograms may reveal changes in tumour heterogeneity.

AB - Background and methods Diffusion-weighted wholebody imaging with background body signal subtraction was introduced as a qualitative approach to detecting metastases in the body. A liver-mimicking phantom with embedded tumours that could be moved to replicate respiratory motion was developed to assess its ability to accurately quantify ADC values. Results Mean tumour ADC values were unaltered by the motion; however, a significant (p < 0.05) increase in the spread of ADC values was measured, even for relatively large tumours. Conclusions These findings may be of significance in cancer therapy monitoring where subtle changes in ADC histograms may reveal changes in tumour heterogeneity.

KW - Apparent diffusion coefficient

KW - DWIBS

KW - Diffusion-weighted imaging

KW - Liver Free breathing

KW - Motion phantom

UR - https://www.scopus.com/pages/publications/84865029688

U2 - 10.1007/s10334-012-0311-1

DO - 10.1007/s10334-012-0311-1

M3 - Article

SN - 0968-5243

VL - 25

SP - 263

EP - 266

JO - Magnetic Resonance Materials in Physics, Biology and Medicine

JF - Magnetic Resonance Materials in Physics, Biology and Medicine

IS - 4

ER -

Effect of motion on the ADC quantification accuracy of whole-body DWIBS

Abstract

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Keywords

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