Abstract
Background and methods Diffusion-weighted wholebody imaging with background body signal subtraction was introduced as a qualitative approach to detecting metastases in the body. A liver-mimicking phantom with embedded tumours that could be moved to replicate respiratory motion was developed to assess its ability to accurately quantify ADC values. Results Mean tumour ADC values were unaltered by the motion; however, a significant (p < 0.05) increase in the spread of ADC values was measured, even for relatively large tumours. Conclusions These findings may be of significance in cancer therapy monitoring where subtle changes in ADC histograms may reveal changes in tumour heterogeneity.
Original language | English |
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Pages (from-to) | 263-266 |
Number of pages | 4 |
Journal | Magnetic Resonance Materials in Physics, Biology and Medicine |
Volume | 25 |
Issue number | 4 |
DOIs | |
Publication status | Published - Aug 2012 |
Keywords
- Apparent diffusion coefficient
- DWIBS
- Diffusion-weighted imaging
- Liver Free breathing
- Motion phantom