TY - JOUR
T1 - Discrimination of cathinone regioisomers, sold as 'legal highs', by Raman spectroscopy
AU - Christie, R.
AU - Horan, E.
AU - Fox, J.
AU - O'Donnell, C.
AU - Byrne, H. J.
AU - Mcdermott, S.
AU - Power, J.
AU - Kavanagh, P.
PY - 2014
Y1 - 2014
N2 - The discrimination of a cross section of cathinone regioisomers, sold as 'legal highs', using Raman spectroscopy, is reported here. Mephedrone and flephedrone were identified in 'legal high' products sold in Irish head shops, and their 2, 3 and 4-isomers were synthesized as reference standards. The 3,4-methylenedioxy substituted cathinones, methylone, butylone and methylenedioxypyrovalerone (MDPV), were also identified in 'legal highs' and their 2,3-isomers were synthesized for comparison. In addition, alpha- and beta-naphyrone were synthesized. Raman spectra of all the isomers were obtained using far-red excitation (785 nm) and it was found possible to discriminate the isomers of each substituted cathinone. In addition, Raman spectra were also recorded for a number of head shop products and, by comparison with the reference standards, correct isomer assignment for 4-mephedrone, 3-flephedrone, 3,4-methylone, 3,4-butylone, 3,4-MDPV, alpha-naphyrone and beta-naphyrone was achieved, thus providing a non-destructive, high-throughput and minimal sample preparation technique for the discrimination of such drug isomers.
AB - The discrimination of a cross section of cathinone regioisomers, sold as 'legal highs', using Raman spectroscopy, is reported here. Mephedrone and flephedrone were identified in 'legal high' products sold in Irish head shops, and their 2, 3 and 4-isomers were synthesized as reference standards. The 3,4-methylenedioxy substituted cathinones, methylone, butylone and methylenedioxypyrovalerone (MDPV), were also identified in 'legal highs' and their 2,3-isomers were synthesized for comparison. In addition, alpha- and beta-naphyrone were synthesized. Raman spectra of all the isomers were obtained using far-red excitation (785 nm) and it was found possible to discriminate the isomers of each substituted cathinone. In addition, Raman spectra were also recorded for a number of head shop products and, by comparison with the reference standards, correct isomer assignment for 4-mephedrone, 3-flephedrone, 3,4-methylone, 3,4-butylone, 3,4-MDPV, alpha-naphyrone and beta-naphyrone was achieved, thus providing a non-destructive, high-throughput and minimal sample preparation technique for the discrimination of such drug isomers.
KW - Flephedrone
KW - MDPV
KW - Mephedrone
KW - Methylone
KW - Naphyrone
KW - Raman
UR - https://www.scopus.com/pages/publications/84904568126
U2 - 10.1002/dta.1518
DO - 10.1002/dta.1518
M3 - Article
C2 - 23900999
AN - SCOPUS:84904568126
SN - 1942-7603
VL - 6
SP - 651
EP - 657
JO - Drug Testing and Analysis
JF - Drug Testing and Analysis
IS - 7-8
ER -