Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity

Bernadette S. Creaven; Michael Devereux; Dariusz Karcz; Andrew Kellett; Malachy McCann; Andy Noble; Maureen Walsh

doi:10.1016/j.jinorgbio.2009.05.017

Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity

Bernadette S. Creaven, Michael Devereux, Dariusz Karcz, Andrew Kellett, Malachy McCann, Andy Noble, Maureen Walsh

Research output: Contribution to journal › Article › peer-review

Abstract

The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a-3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B.

Original language	English
Pages (from-to)	1196-1203
Number of pages	8
Journal	Journal of Inorganic Biochemistry
Volume	103
Issue number	9
DOIs	https://doi.org/10.1016/j.jinorgbio.2009.05.017
Publication status	Published - Sep 2009

Keywords

Antifungal
Copper
Coumarin
Metal complexes
X-ray crystal structures

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10.1016/j.jinorgbio.2009.05.017

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title = "Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity",

abstract = "The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a-3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B.",

keywords = "Antifungal, Copper, Coumarin, Metal complexes, X-ray crystal structures",

author = "Creaven, \{Bernadette S.\} and Michael Devereux and Dariusz Karcz and Andrew Kellett and Malachy McCann and Andy Noble and Maureen Walsh",

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T1 - Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity

AU - Creaven, Bernadette S.

AU - Devereux, Michael

AU - Karcz, Dariusz

AU - Kellett, Andrew

AU - McCann, Malachy

AU - Noble, Andy

AU - Walsh, Maureen

PY - 2009/9

Y1 - 2009/9

N2 - The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a-3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B.

AB - The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a-2k) in good yields. Subsequent reaction of these ligands with copper(II) acetate yielded Cu(II) complexes (3a-3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B.

KW - Antifungal

KW - Copper

KW - Coumarin

KW - Metal complexes

KW - X-ray crystal structures

UR - https://www.scopus.com/pages/publications/68949220072

U2 - 10.1016/j.jinorgbio.2009.05.017

DO - 10.1016/j.jinorgbio.2009.05.017

M3 - Article

C2 - 19631386

AN - SCOPUS:68949220072

SN - 0162-0134

VL - 103

SP - 1196

EP - 1203

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 9

ER -

Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity

Abstract

Keywords

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