Combination Strategies for Targeted Delivery of Nanoparticles for Cancer Therapy

Zhonglei He; Kangze Liu; Hugh J. Byrne; Patrick J. Cullen; Furong Tian; James F. Curtin

doi:10.1016/B978-0-12-814029-1.00008-9

Combination Strategies for Targeted Delivery of Nanoparticles for Cancer Therapy

Zhonglei He, Kangze Liu, Hugh J. Byrne, Patrick J. Cullen, Furong Tian, James F. Curtin

School of Food Science and Environmental Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

11 Citations (Scopus)

Abstract

Pharmaceuticals, and more recently biopharmaceuticals, have become the mainstay for antineoplastic treatments in combination with surgical interventions and radiation therapy. In recent years, advances have been made in the development of nanotechnological interventions for the treatment of cancer alone or in combination with existing therapeutic modalities. Nanotechnology used for therapeutic drug delivery and sensitization of photodynamic, sonodynamic, and radiotherapy are now being tested in preclinical and clinical trials for the treatment of cancer. This article reviews the current state of the art for nanotechnology therapies with an emphasis on targeted drug delivery and the observed and likely benefits when used in combination with existing therapeutic approaches.

Original language	English
Title of host publication	Applications of Targeted Nano Drugs and Delivery Systems
Subtitle of host publication	Nanoscience and Nanotechnology in Drug Delivery
Publisher	Elsevier
Pages	191-219
Number of pages	29
ISBN (Electronic)	9780128140291
DOIs	https://doi.org/10.1016/B978-0-12-814029-1.00008-9
Publication status	Published - 1 Jan 2018

Keywords

Nanoparticles
Nanotechnology
Photodynamic therapy
Radiotherapy
Sensitization
Sonodynamic therapy
Targeted delivery

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10.1016/B978-0-12-814029-1.00008-9

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abstract = "Pharmaceuticals, and more recently biopharmaceuticals, have become the mainstay for antineoplastic treatments in combination with surgical interventions and radiation therapy. In recent years, advances have been made in the development of nanotechnological interventions for the treatment of cancer alone or in combination with existing therapeutic modalities. Nanotechnology used for therapeutic drug delivery and sensitization of photodynamic, sonodynamic, and radiotherapy are now being tested in preclinical and clinical trials for the treatment of cancer. This article reviews the current state of the art for nanotechnology therapies with an emphasis on targeted drug delivery and the observed and likely benefits when used in combination with existing therapeutic approaches.",

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AU - He, Zhonglei

AU - Liu, Kangze

AU - Byrne, Hugh J.

AU - Cullen, Patrick J.

AU - Tian, Furong

AU - Curtin, James F.

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AB - Pharmaceuticals, and more recently biopharmaceuticals, have become the mainstay for antineoplastic treatments in combination with surgical interventions and radiation therapy. In recent years, advances have been made in the development of nanotechnological interventions for the treatment of cancer alone or in combination with existing therapeutic modalities. Nanotechnology used for therapeutic drug delivery and sensitization of photodynamic, sonodynamic, and radiotherapy are now being tested in preclinical and clinical trials for the treatment of cancer. This article reviews the current state of the art for nanotechnology therapies with an emphasis on targeted drug delivery and the observed and likely benefits when used in combination with existing therapeutic approaches.

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KW - Nanotechnology

KW - Photodynamic therapy

KW - Radiotherapy

KW - Sensitization

KW - Sonodynamic therapy

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Combination Strategies for Targeted Delivery of Nanoparticles for Cancer Therapy

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Keywords

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