Biomedical applications of vibrational spectroscopy: Oral cancer diagnostics

Hugh J. Byrne; Isha Behl; Genecy Calado; Ola Ibrahim; Mary Toner; Sheila Galvin; Claire M. Healy; Stephen Flint; Fiona M. Lyng

doi:10.1016/j.saa.2021.119470

Biomedical applications of vibrational spectroscopy: Oral cancer diagnostics

Hugh J. Byrne
, Isha Behl
, Genecy Calado
, Ola Ibrahim
, Mary Toner
, Sheila Galvin
, Claire M. Healy
, Stephen Flint
, Fiona M. Lyng

Research output: Contribution to journal › Article › peer-review

Abstract

Vibrational spectroscopy, based on either infrared absorption or Raman scattering, has attracted increasing attention for biomedical applications. Proof of concept explorations for diagnosis of oral potentially malignant disorders and cancer are reviewed, and recent advances critically appraised. Specific examples of applications of Raman microspectroscopy for analysis of histological, cytological and saliva samples are presented for illustrative purposes, and the future prospects, ultimately for routine, chairside in vivo screening are discussed.

Original language	English
Article number	119470
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	252
DOIs	https://doi.org/10.1016/j.saa.2021.119470
Publication status	Published - 5 May 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Infrared spectroscopy
Oral cancer
Oral pre-cancer
Potentially malignant lesions disease diagnostics
Premalignant lesions
Raman spectroscopy
Vibrational spectroscopy

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10.1016/j.saa.2021.119470

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title = "Biomedical applications of vibrational spectroscopy: Oral cancer diagnostics",

abstract = "Vibrational spectroscopy, based on either infrared absorption or Raman scattering, has attracted increasing attention for biomedical applications. Proof of concept explorations for diagnosis of oral potentially malignant disorders and cancer are reviewed, and recent advances critically appraised. Specific examples of applications of Raman microspectroscopy for analysis of histological, cytological and saliva samples are presented for illustrative purposes, and the future prospects, ultimately for routine, chairside in vivo screening are discussed.",

keywords = "Infrared spectroscopy, Oral cancer, Oral pre-cancer, Potentially malignant lesions disease diagnostics, Premalignant lesions, Raman spectroscopy, Vibrational spectroscopy",

author = "Byrne, \{Hugh J.\} and Isha Behl and Genecy Calado and Ola Ibrahim and Mary Toner and Sheila Galvin and Healy, \{Claire M.\} and Stephen Flint and Lyng, \{Fiona M.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

year = "2021",

month = may,

day = "5",

doi = "10.1016/j.saa.2021.119470",

language = "English",

volume = "252",

journal = "Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy",

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TY - JOUR

T1 - Biomedical applications of vibrational spectroscopy

T2 - Oral cancer diagnostics

AU - Byrne, Hugh J.

AU - Behl, Isha

AU - Calado, Genecy

AU - Ibrahim, Ola

AU - Toner, Mary

AU - Galvin, Sheila

AU - Healy, Claire M.

AU - Flint, Stephen

AU - Lyng, Fiona M.

PY - 2021/5/5

Y1 - 2021/5/5

N2 - Vibrational spectroscopy, based on either infrared absorption or Raman scattering, has attracted increasing attention for biomedical applications. Proof of concept explorations for diagnosis of oral potentially malignant disorders and cancer are reviewed, and recent advances critically appraised. Specific examples of applications of Raman microspectroscopy for analysis of histological, cytological and saliva samples are presented for illustrative purposes, and the future prospects, ultimately for routine, chairside in vivo screening are discussed.

AB - Vibrational spectroscopy, based on either infrared absorption or Raman scattering, has attracted increasing attention for biomedical applications. Proof of concept explorations for diagnosis of oral potentially malignant disorders and cancer are reviewed, and recent advances critically appraised. Specific examples of applications of Raman microspectroscopy for analysis of histological, cytological and saliva samples are presented for illustrative purposes, and the future prospects, ultimately for routine, chairside in vivo screening are discussed.

KW - Infrared spectroscopy

KW - Oral cancer

KW - Oral pre-cancer

KW - Potentially malignant lesions disease diagnostics

KW - Premalignant lesions

KW - Raman spectroscopy

KW - Vibrational spectroscopy

UR - https://www.scopus.com/pages/publications/85099709772

U2 - 10.1016/j.saa.2021.119470

DO - 10.1016/j.saa.2021.119470

M3 - Article

C2 - 33503511

AN - SCOPUS:85099709772

SN - 1386-1425

VL - 252

JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

M1 - 119470

ER -

Biomedical applications of vibrational spectroscopy: Oral cancer diagnostics

Abstract

UN SDGs

Keywords

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