TY - JOUR
T1 - Associations of maternal and fetal SCD-1 markers with infant anthropometry and maternal diet
T2 - Findings from the ROLO study
AU - Marchioro, Linda
AU - Hellmuth, Christian
AU - Uhl, Olaf
AU - Geraghty, Aisling A.
AU - O'Brien, Eileen C.
AU - Horan, Mary K.
AU - Donnelly, Jean M.
AU - Kirchberg, Franca F.
AU - Koletzko, Berthold
AU - McAuliffe, Fionnuala M.
N1 - Publisher Copyright:
© 2019
PY - 2020/7
Y1 - 2020/7
N2 - Background: Elevated stearoyl-CoA desaturase 1 (SCD-1) activity showed associations with obesity in cross-sectional studies. In non-pregnant populations, nutrition regulates SCD-1 transcription and activity. Objective: To investigate the longitudinal associations of maternal and fetal SCD-1 activity markers with infant anthropometry up to 2 years of age, and to explore how selected dietary intakes modulate SCD-1 activity in pregnancy. Methods: As a secondary analysis from the ROLO intervention study, which was conducted in a population at risk for macrosomia, non-esterified fatty acids (NEFA) from maternal plasma at 13 and 28 weeks' gestation and in cord blood were measured via liquid-chromatography-mass-spectrometry. Fatty acid ratios 18:1/18:0 and 16:1/16:0 were used as markers for SCD-1 activity (‘desaturation indices’, DIs). Relationships of DIs with infant anthropometry up to 2 years of age and maternal dietary parameters during pregnancy were investigated using adjusted linear regression models and p-values correction for multiple testing. Results: 18:1/18:0, but not 16:1/16:0, was associated with measures of infant anthropometry at birth (maternal and fetal markers) and up to 2 years of age (maternal markers only). Dietary intakes did not show strong associations with 18:1/18:0, but 16:1/16:0 was associated with absolute and relative dietary intakes. Conclusions: In a population at risk for macrosomia, maternal SCD-1 activity measured via 18:1/18:0 was involved in the fetal programming of infant obesity, but could not be substantially modulated by short-term diet in pregnancy. Clinical trial registration: ISRCTN Registration number: ISRCTN54392969 (http://www.isrctn.com/ISRCTN54392969).
AB - Background: Elevated stearoyl-CoA desaturase 1 (SCD-1) activity showed associations with obesity in cross-sectional studies. In non-pregnant populations, nutrition regulates SCD-1 transcription and activity. Objective: To investigate the longitudinal associations of maternal and fetal SCD-1 activity markers with infant anthropometry up to 2 years of age, and to explore how selected dietary intakes modulate SCD-1 activity in pregnancy. Methods: As a secondary analysis from the ROLO intervention study, which was conducted in a population at risk for macrosomia, non-esterified fatty acids (NEFA) from maternal plasma at 13 and 28 weeks' gestation and in cord blood were measured via liquid-chromatography-mass-spectrometry. Fatty acid ratios 18:1/18:0 and 16:1/16:0 were used as markers for SCD-1 activity (‘desaturation indices’, DIs). Relationships of DIs with infant anthropometry up to 2 years of age and maternal dietary parameters during pregnancy were investigated using adjusted linear regression models and p-values correction for multiple testing. Results: 18:1/18:0, but not 16:1/16:0, was associated with measures of infant anthropometry at birth (maternal and fetal markers) and up to 2 years of age (maternal markers only). Dietary intakes did not show strong associations with 18:1/18:0, but 16:1/16:0 was associated with absolute and relative dietary intakes. Conclusions: In a population at risk for macrosomia, maternal SCD-1 activity measured via 18:1/18:0 was involved in the fetal programming of infant obesity, but could not be substantially modulated by short-term diet in pregnancy. Clinical trial registration: ISRCTN Registration number: ISRCTN54392969 (http://www.isrctn.com/ISRCTN54392969).
KW - Fatty acid metabolism
KW - Fetal programming
KW - Infant adiposity
KW - Maternal nutrition
KW - Pregnancy
KW - Stearoyl-CoA desaturase-1
UR - http://www.scopus.com/inward/record.url?scp=85075474447&partnerID=8YFLogxK
U2 - 10.1016/j.clnu.2019.08.030
DO - 10.1016/j.clnu.2019.08.030
M3 - Article
C2 - 31708235
AN - SCOPUS:85075474447
SN - 0261-5614
VL - 39
SP - 2129
EP - 2136
JO - Clinical Nutrition
JF - Clinical Nutrition
IS - 7
ER -