Abstract
Objective: To examine the association between maternal metabolic parameters in pregnancy and growth trajectories up to 5 years of age. Methods: Data from mother–child pairs who participated in the ROLO study, a randomized trial examining the impact of a low glycaemic index diet on the recurrence of macrosomia, were analysed. Fetal and child growth trajectories were developed from longitudinal measurements from 20 weeks gestation up to 5 years of age. We examined associations between maternal fasting glucose, insulin, HOMA-IR and leptin, taken in early pregnancy (14–16 weeks) and late pregnancy (28 weeks), and weight (kg) and abdominal circumference (cm) trajectories using linear spline multilevel models. Results: We found no strong evidence of associations between any maternal metabolic parameters and fetal to childhood weight and abdominal circumference trajectories from 20 weeks gestation to 5 years. Conclusion: In a cohort of women with obesity with infants at risk of macrosomia, maternal metabolic markers were not strongly associated with trajectories of weight or abdominal circumference from 20 weeks gestation to 5 years of age.
Original language | English |
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Article number | e12976 |
Journal | Pediatric Obesity |
Volume | 18 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2023 |
Externally published | Yes |
Keywords
- child growth
- fetal growth
- glucose
- growth trajectories
- insulin