Assessing the spectrochemical signatures of skin components using FTIR microspectroscopy

Cassio A. Lima, Luciana Correa, Hugh J. Byrne, Denise M. Zezell

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Fourier Transform Infrared (FTIR) spectroscopy is a label-free analytical technique used to evaluate the chemical profile of a sample based on its molecular vibrations. The potential dermatological applications of FTIR spectroscopy has been well demonstrated over the past decades through many proof-of-concept studies evaluating cancerous and non-cancerous cutaneous diseases. Considering that the correctly identification of skin components plays an important role in the study of cutaneous diseases, the present study aims to evaluate the spectrochemical signatures of dermis and epidermis based on the pixels of a FTIR hyperspectral image collected from healthy skin.

Original languageEnglish
Title of host publicationClinical and Preclinical Optical Diagnostics II
EditorsJ. Quincy Brown, Ton G. van Leeuwen
PublisherSPIE
ISBN (Electronic)9781510628397
DOIs
Publication statusPublished - 2019
EventClinical and Preclinical Optical Diagnostics II 2019 - Munich, Germany
Duration: 23 Jun 201925 Jun 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11073
ISSN (Print)1605-7422

Conference

ConferenceClinical and Preclinical Optical Diagnostics II 2019
Country/TerritoryGermany
CityMunich
Period23/06/1925/06/19

Keywords

  • FTIR microspectroscopy
  • Image reconstruction
  • K-means clustering analysis
  • Skin imaging

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