[Ag2(aca)2]n and [Ag4(aca)4(NH3)2] (acaH = 9-anthracenecarboxylic acid): Synthesis, X-ray crystal structures, antimicrobial and anti-cancer activities

Robert Curran; Joanne Lenehan; Malachy McCann; Kevin Kavanagh; Michael Devereux; Denise A. Egan; Grace Clifford; Kevin Keane; Bernadette S. Creaven; Vickie McKee

doi:10.1016/j.inoche.2007.06.021

[Ag₂(aca)₂]_n and [Ag₄(aca)₄(NH₃)₂] (acaH = 9-anthracenecarboxylic acid): Synthesis, X-ray crystal structures, antimicrobial and anti-cancer activities

Robert Curran, Joanne Lenehan, Malachy McCann, Kevin Kavanagh, Michael Devereux, Denise A. Egan, Grace Clifford, Kevin Keane, Bernadette S. Creaven, Vickie McKee

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

[Ag₂(9-aca)₂]_n and [Ag₄(9-aca)₄(NH₃)₂] (9-acaH = 9-anthracenecarboxylic acid) have been prepared and structurally characterized. [Ag₂(9-aca)₂]_n consists of polymeric ribbons of linked disilver(I) syn-syn bridged dicarboxylate units. [Ag₄(9-aca)₄(NH₃)₂] is tetrameric and centrosymmetric, with two syn-syn bridging carboxylates linked to the bimetallic Ag-Ag core and a further two syn-anti bridged carboxylate ligands in the equatorial plane, being coordinated to one Ag in the bimetallic core and to a second Ag, with the latter also bonded to an NH₃ ligand. In vitro studies show that both complexes are extremely cytotoxic against selected human fungal and bacterial pathogens, and each complex also greatly inhibits the growth of two mammalian cancer cell lines.

Original language	English
Pages (from-to)	1149-1153
Number of pages	5
Journal	Inorganic Chemistry Communications
Volume	10
Issue number	10
DOIs	https://doi.org/10.1016/j.inoche.2007.06.021
Publication status	Published - Oct 2007

Keywords

9-Anthracenecarboxylic acid
Anti-bacterial
Anti-cancer
Anti-fungal
Silver(I)
X-ray structure

Access to Document

10.1016/j.inoche.2007.06.021

Cite this

Curran, R., Lenehan, J., McCann, M., Kavanagh, K., Devereux, M., Egan, D. A., Clifford, G., Keane, K., Creaven, B. S., & McKee, V. (2007). [Ag₂(aca)₂]_n and [Ag₄(aca)₄(NH₃)₂] (acaH = 9-anthracenecarboxylic acid): Synthesis, X-ray crystal structures, antimicrobial and anti-cancer activities. Inorganic Chemistry Communications, 10(10), 1149-1153. https://doi.org/10.1016/j.inoche.2007.06.021

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title = "[Ag2(aca)2]n and [Ag4(aca)4(NH3)2] (acaH = 9-anthracenecarboxylic acid): Synthesis, X-ray crystal structures, antimicrobial and anti-cancer activities",

abstract = "[Ag2(9-aca)2]n and [Ag4(9-aca)4(NH3)2] (9-acaH = 9-anthracenecarboxylic acid) have been prepared and structurally characterized. [Ag2(9-aca)2]n consists of polymeric ribbons of linked disilver(I) syn-syn bridged dicarboxylate units. [Ag4(9-aca)4(NH3)2] is tetrameric and centrosymmetric, with two syn-syn bridging carboxylates linked to the bimetallic Ag-Ag core and a further two syn-anti bridged carboxylate ligands in the equatorial plane, being coordinated to one Ag in the bimetallic core and to a second Ag, with the latter also bonded to an NH3 ligand. In vitro studies show that both complexes are extremely cytotoxic against selected human fungal and bacterial pathogens, and each complex also greatly inhibits the growth of two mammalian cancer cell lines.",

keywords = "9-Anthracenecarboxylic acid, Anti-bacterial, Anti-cancer, Anti-fungal, Silver(I), X-ray structure",

author = "Robert Curran and Joanne Lenehan and Malachy McCann and Kevin Kavanagh and Michael Devereux and Egan, {Denise A.} and Grace Clifford and Kevin Keane and Creaven, {Bernadette S.} and Vickie McKee",

year = "2007",

month = oct,

doi = "10.1016/j.inoche.2007.06.021",

language = "English",

volume = "10",

pages = "1149--1153",

journal = "Inorganic Chemistry Communications",

issn = "1387-7003",

publisher = "Elsevier BV",

number = "10",

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Curran, R, Lenehan, J, McCann, M, Kavanagh, K, Devereux, M, Egan, DA, Clifford, G, Keane, K, Creaven, BS & McKee, V 2007, '[Ag₂(aca)₂]_n and [Ag₄(aca)₄(NH₃)₂] (acaH = 9-anthracenecarboxylic acid): Synthesis, X-ray crystal structures, antimicrobial and anti-cancer activities', Inorganic Chemistry Communications, vol. 10, no. 10, pp. 1149-1153. https://doi.org/10.1016/j.inoche.2007.06.021

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T1 - [Ag2(aca)2]n and [Ag4(aca)4(NH3)2] (acaH = 9-anthracenecarboxylic acid)

T2 - Synthesis, X-ray crystal structures, antimicrobial and anti-cancer activities

AU - Curran, Robert

AU - Lenehan, Joanne

AU - McCann, Malachy

AU - Kavanagh, Kevin

AU - Devereux, Michael

AU - Egan, Denise A.

AU - Clifford, Grace

AU - Keane, Kevin

AU - Creaven, Bernadette S.

AU - McKee, Vickie

PY - 2007/10

Y1 - 2007/10

N2 - [Ag2(9-aca)2]n and [Ag4(9-aca)4(NH3)2] (9-acaH = 9-anthracenecarboxylic acid) have been prepared and structurally characterized. [Ag2(9-aca)2]n consists of polymeric ribbons of linked disilver(I) syn-syn bridged dicarboxylate units. [Ag4(9-aca)4(NH3)2] is tetrameric and centrosymmetric, with two syn-syn bridging carboxylates linked to the bimetallic Ag-Ag core and a further two syn-anti bridged carboxylate ligands in the equatorial plane, being coordinated to one Ag in the bimetallic core and to a second Ag, with the latter also bonded to an NH3 ligand. In vitro studies show that both complexes are extremely cytotoxic against selected human fungal and bacterial pathogens, and each complex also greatly inhibits the growth of two mammalian cancer cell lines.

AB - [Ag2(9-aca)2]n and [Ag4(9-aca)4(NH3)2] (9-acaH = 9-anthracenecarboxylic acid) have been prepared and structurally characterized. [Ag2(9-aca)2]n consists of polymeric ribbons of linked disilver(I) syn-syn bridged dicarboxylate units. [Ag4(9-aca)4(NH3)2] is tetrameric and centrosymmetric, with two syn-syn bridging carboxylates linked to the bimetallic Ag-Ag core and a further two syn-anti bridged carboxylate ligands in the equatorial plane, being coordinated to one Ag in the bimetallic core and to a second Ag, with the latter also bonded to an NH3 ligand. In vitro studies show that both complexes are extremely cytotoxic against selected human fungal and bacterial pathogens, and each complex also greatly inhibits the growth of two mammalian cancer cell lines.

KW - 9-Anthracenecarboxylic acid

KW - Anti-bacterial

KW - Anti-cancer

KW - Anti-fungal

KW - Silver(I)

KW - X-ray structure

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SN - 1387-7003

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EP - 1153

JO - Inorganic Chemistry Communications

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