Adenoviral-mediated gene transferinto the canine brain in vivo: Commentary

Marianela Candolfi; E. Antonio Chiocca; Kurt Kroeger; G. Elizabeth Pluhar; Josee Bergeron; Mariana Puntel; James Curtin; Elizabeth A. McNiel; Andrew B. Freese; John R. Ohlfest; Peter Moore; Pedro R. Lowenstein; Maria G. Castro

doi:10.1227/01.NEU.0000249210.89096.6C

Adenoviral-mediated gene transferinto the canine brain in vivo: Commentary

Marianela Candolfi, E. Antonio Chiocca, Kurt Kroeger, G. Elizabeth Pluhar, Josee Bergeron, Mariana Puntel, James Curtin, Elizabeth A. McNiel, Andrew B. Freese, John R. Ohlfest, Peter Moore, Pedro R. Lowenstein, Maria G. Castro

Research output: Contribution to journal › Comment/debate

Abstract

Glioblastoma multiforme (GBM) is a devastating brain tumor for which there is no cure. Adenoviral-mediated transfer of conditional cytotoxic (herpes simplex virus [HSV] 1-derived thymidine kinase [TK]) and immunostimulatory (Fms-like tyrosine kinase 3 ligand [Flt3L]) transgenes elicited immune-mediated long-term survival in a syngeneic intracranial GBM model in rodents. However, the lack of a large GBM animal model makes it difficult to predict the outcome of therapies in humans. Dogs develop spontaneous GBM that closely resemble the human disease; therefore, they constitute an excellent large animal model. We assayed the transduction efficiency of adenoviral vectors (Ads) encoding β-galactosidase (βGal), TK, and Flt3L in J3T dog GBM cells in vitro and in the dog brain in vivo.

Original language	English
Pages (from-to)	178
Number of pages	1
Journal	Neurosurgery
Volume	60
Issue number	1
DOIs	https://doi.org/10.1227/01.NEU.0000249210.89096.6C
Publication status	Published - Jan 2007
Externally published	Yes

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@article{b8f26b76d4c54321be6227c24e195d62,

title = "Adenoviral-mediated gene transferinto the canine brain in vivo: Commentary",

abstract = "Glioblastoma multiforme (GBM) is a devastating brain tumor for which there is no cure. Adenoviral-mediated transfer of conditional cytotoxic (herpes simplex virus [HSV] 1-derived thymidine kinase [TK]) and immunostimulatory (Fms-like tyrosine kinase 3 ligand [Flt3L]) transgenes elicited immune-mediated long-term survival in a syngeneic intracranial GBM model in rodents. However, the lack of a large GBM animal model makes it difficult to predict the outcome of therapies in humans. Dogs develop spontaneous GBM that closely resemble the human disease; therefore, they constitute an excellent large animal model. We assayed the transduction efficiency of adenoviral vectors (Ads) encoding β-galactosidase (βGal), TK, and Flt3L in J3T dog GBM cells in vitro and in the dog brain in vivo.",

author = "Marianela Candolfi and Chiocca, \{E. Antonio\} and Kurt Kroeger and Pluhar, \{G. Elizabeth\} and Josee Bergeron and Mariana Puntel and James Curtin and McNiel, \{Elizabeth A.\} and Freese, \{Andrew B.\} and Ohlfest, \{John R.\} and Peter Moore and Lowenstein, \{Pedro R.\} and Castro, \{Maria G.\}",

year = "2007",

month = jan,

doi = "10.1227/01.NEU.0000249210.89096.6C",

language = "English",

volume = "60",

pages = "178",

journal = "Neurosurgery",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Adenoviral-mediated gene transferinto the canine brain in vivo

T2 - Commentary

AU - Candolfi, Marianela

AU - Chiocca, E. Antonio

AU - Kroeger, Kurt

AU - Pluhar, G. Elizabeth

AU - Bergeron, Josee

AU - Puntel, Mariana

AU - Curtin, James

AU - McNiel, Elizabeth A.

AU - Freese, Andrew B.

AU - Ohlfest, John R.

AU - Moore, Peter

AU - Lowenstein, Pedro R.

AU - Castro, Maria G.

PY - 2007/1

Y1 - 2007/1

N2 - Glioblastoma multiforme (GBM) is a devastating brain tumor for which there is no cure. Adenoviral-mediated transfer of conditional cytotoxic (herpes simplex virus [HSV] 1-derived thymidine kinase [TK]) and immunostimulatory (Fms-like tyrosine kinase 3 ligand [Flt3L]) transgenes elicited immune-mediated long-term survival in a syngeneic intracranial GBM model in rodents. However, the lack of a large GBM animal model makes it difficult to predict the outcome of therapies in humans. Dogs develop spontaneous GBM that closely resemble the human disease; therefore, they constitute an excellent large animal model. We assayed the transduction efficiency of adenoviral vectors (Ads) encoding β-galactosidase (βGal), TK, and Flt3L in J3T dog GBM cells in vitro and in the dog brain in vivo.

AB - Glioblastoma multiforme (GBM) is a devastating brain tumor for which there is no cure. Adenoviral-mediated transfer of conditional cytotoxic (herpes simplex virus [HSV] 1-derived thymidine kinase [TK]) and immunostimulatory (Fms-like tyrosine kinase 3 ligand [Flt3L]) transgenes elicited immune-mediated long-term survival in a syngeneic intracranial GBM model in rodents. However, the lack of a large GBM animal model makes it difficult to predict the outcome of therapies in humans. Dogs develop spontaneous GBM that closely resemble the human disease; therefore, they constitute an excellent large animal model. We assayed the transduction efficiency of adenoviral vectors (Ads) encoding β-galactosidase (βGal), TK, and Flt3L in J3T dog GBM cells in vitro and in the dog brain in vivo.

UR - https://www.scopus.com/pages/publications/33846223914

U2 - 10.1227/01.NEU.0000249210.89096.6C

DO - 10.1227/01.NEU.0000249210.89096.6C

M3 - Comment/debate

AN - SCOPUS:33846223914

SN - 0148-396X

VL - 60

SP - 178

JO - Neurosurgery

JF - Neurosurgery

IS - 1

ER -

Adenoviral-mediated gene transferinto the canine brain in vivo: Commentary

Abstract

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