TY - JOUR
T1 - A new phenanthroline–oxazine ligand
T2 - Synthesis, coordination chemistry and atypical DNA binding interaction
AU - Mc Cann, Malachy
AU - Mc Ginley, John
AU - Ni, Kaijie
AU - O’connor, Mark
AU - Kavanagh, Kevin
AU - Mc Kee, Vickie
AU - Colleran, John
AU - Devereux, Michael
AU - Gathergood, Nicholas
AU - Barron, Niall
AU - Prisecaru, Andreea
AU - Kellett, Andrew
PY - 2013/2/21
Y1 - 2013/2/21
N2 - 1,10-Phenanthroline-5,6-dione and l-tyrosine methyl ester react to form phenanthroline–oxazine (PDT) from which [Cu(PDT)2](ClO4)2 and [Ag(PDT)2]ClO4·2MeOH are obtained. Binding to calf-thymus DNA by Ag(i) and Cu(ii) PDT complexes exceed bis-1,10-phenanthroline analogues and the minor groove binding drugs, pentamidine and netropsin. Furthermore, unlike the artificial metallonuclease, [Cu(phen)2]2+, the [Cu(PDT)2]2+ complex does not cleave DNA in the presence of added reductant indicating unique interaction with DNA.
AB - 1,10-Phenanthroline-5,6-dione and l-tyrosine methyl ester react to form phenanthroline–oxazine (PDT) from which [Cu(PDT)2](ClO4)2 and [Ag(PDT)2]ClO4·2MeOH are obtained. Binding to calf-thymus DNA by Ag(i) and Cu(ii) PDT complexes exceed bis-1,10-phenanthroline analogues and the minor groove binding drugs, pentamidine and netropsin. Furthermore, unlike the artificial metallonuclease, [Cu(phen)2]2+, the [Cu(PDT)2]2+ complex does not cleave DNA in the presence of added reductant indicating unique interaction with DNA.
UR - https://www.scopus.com/pages/publications/84875960682
U2 - 10.1039/c3cc38710k
DO - 10.1039/c3cc38710k
M3 - Article
C2 - 23407675
AN - SCOPUS:84875960682
SN - 1359-7345
VL - 49
SP - 2341
EP - 2343
JO - Chemical Communications
JF - Chemical Communications
IS - 23
ER -