A mathematical analysis of drug dissolution in the USP flow through apparatus

David McDonnell; D. M. D’Arcy; L. J. Crane; Brendan Redmond

doi:10.1007/s00231-017-2151-z

A mathematical analysis of drug dissolution in the USP flow through apparatus

David McDonnell, D. M. D’Arcy, L. J. Crane, Brendan Redmond

Research output: Contribution to journal › Article › peer-review

Abstract

This paper applies boundary layer theory to the process of drug dissolution in the USP (United States Pharmacopeia) Flow Through Apparatus. The mass transfer rate from the vertical planar surface of a compact within the device is examined. The theoretical results obtained are then compared with those of experiment. The paper also examines the effect on the dissolution process caused by the interaction between natural and forced convection within the apparatus and the introduction of additional boundaries.

Original language	English
Pages (from-to)	793-801
Number of pages	9
Journal	Heat and Mass Transfer/Waerme- und Stoffuebertragung
Volume	54
Issue number	3
DOIs	https://doi.org/10.1007/s00231-017-2151-z
Publication status	Published - 1 Mar 2018

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A mathematical analysis of drug dissolution in the USP flow through apparatus

Abstract

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