@inproceedings{d9efa7fe678f40babcfd466089b0237a,
title = "A lead BODIPY-phenylanthracene dyad for application in photodynamic therapy",
abstract = "Over the past four years we have developed BODIPY dyads capable of triplet state generation from charge transfer states generated by photoinduced electron transfer. In the current work we identify a lead compound for application in photodynamic therapy. This system is composed of a phenylanthracene electron donor unit and a dimethyl-substituted BODIPY acceptor unit. We have demonstrated that this compound, in sub-micromolar concentrations, can effectively generate singlet oxygen in polar solvents and induce cytotoxicity in human breast cancer cells (MDA-MB-468) when exposed to light. The photophysical properties of these compounds are chemically tunable and thus open the door not only to a new class of photodynamic therapy photosensitizers, but also agents for triplet-triplet annihilation up-conversion applications.",
keywords = "BODIPY, Photodynamic Therapy, Photosensitizer, Singlet Oxygen, Triplet State",
author = "Susan Callaghan and Filatov, {Mikhail A.} and Huguette Savoie and Boyle, {Ross W.} and Senge, {Mathias O.}",
note = "Publisher Copyright: {\textcopyright} 2019 SPIE.; 17th International Photodynamic Association World Congress 2019 ; Conference date: 28-06-2019 Through 04-07-2019",
year = "2019",
doi = "10.1117/12.2525246",
language = "English",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Tayyaba Hasan",
booktitle = "17th International Photodynamic Association World Congress",
address = "United States",
}